Evidence map›Paper›PMID 39168654›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

GAP43 Located on Corticostriatal Terminals Restrains Novelty-Induced Hyperactivity in Mice.

Irene B Maroto, Carlos Costas-Insua, Carlos Montero-Fernández, Alba Hermoso-López, Margaux Lebouc, Raquel Bajo-Grañeras, Alicia Álvaro-Blázquez, Cristina Blázquez, Astrid Cannich, Giovanni Marsicano and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Irene B MarotoDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.
Carlos Costas-InsuaDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.ORCID 0000-0003-3446-6899
Carlos Montero-FernándezDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.ORCID 0000-0003-1078-2678
Alba Hermoso-LópezDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.
Margaux LeboucUniversity of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux F-33000, France.
Raquel Bajo-GrañerasDepartment of Physiology, School of Medicine, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.
Alicia Álvaro-BlázquezDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.
Cristina BlázquezDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.
Astrid CannichUniversity of Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux F-33000, France.
Giovanni MarsicanoUniversity of Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux F-33000, France.
Ricardo MartínDepartment of Physiology, School of Medicine, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.
Jérôme BaufretonUniversity of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux F-33000, France.
Ignacio Rodríguez-CrespoDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain.
Luigi BellocchioUniversity of Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux F-33000, France.ORCID 0000-0001-7774-3935
Manuel GuzmánDepartment of Biochemistry and Molecular Biology, Schools of Biology and Chemistry, Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid ES-28040, Spain mguzman@quim.ucm.es.ORCID 0000-0001-7475-118X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth-associated protein of 43 kDa (GAP43) is a key cytoskeleton-associated component of the presynaptic terminal that facilitates neuroplasticity. Downregulation of GAP43 expression has been associated to various psychiatric conditions in humans and evokes hippocampus-dependent memory impairments in mice. Despite the extensive studies conducted on hippocampal GAP43 in past decades, however, very little is known about its roles in modulating the excitatory versus inhibitory balance in other brain regions. We recently generated conditional knock-out mice in which the

Indexed as

Corpus StriatumGAP-43 ProteinMice, KnockoutAnimalsCerebral CortexExploratory BehaviorFemaleGABAergic NeuronsHyperkinesisMaleMiceMice, Inbred C57BLPresynaptic TerminalsGAP-43 Proteincannabinoidcorticostriatal circuitryGAP43glutamatergic transmissionlong-term depressionmotor activity

Identifiers

PMID39168654
PMCPMC11426381

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.