Evidence map›Paper›PMID 39169123›Full record

ArticleScientific reports2024

Preliminary investigation on the impact of salty and sugary former foods on pig liver and plasma profiles using OMICS approaches.

Michele Manoni, Alessandra Altomare, Simona Nonnis, Giulio Ferrario, Sharon Mazzoleni, Marco Tretola, Giuseppe Bee, Gabriella Tedeschi, Giancarlo Aldini, Luciano Pinotti

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michele Manoni *Department of Veterinary Medicine and Animal Science (DIVAS), University of Milan, Via dell'Università 6, 26900, Lodi, Italy. michele.manoni@unimi.it.
Alessandra Altomare *Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
Simona NonnisDepartment of Veterinary Medicine and Animal Science (DIVAS), University of Milan, Via dell'Università 6, 26900, Lodi, Italy.
Giulio FerrarioDepartment of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
Sharon MazzoleniDepartment of Veterinary Medicine and Animal Science (DIVAS), University of Milan, Via dell'Università 6, 26900, Lodi, Italy.
Marco TretolaAgroscope, Institute for Livestock Sciences, Rte de la Tioleyre 4, 1725, Posieux, Switzerland.
Giuseppe BeeAgroscope, Institute for Livestock Sciences, Rte de la Tioleyre 4, 1725, Posieux, Switzerland.
Gabriella TedeschiDepartment of Veterinary Medicine and Animal Science (DIVAS), University of Milan, Via dell'Università 6, 26900, Lodi, Italy.
Giancarlo AldiniDepartment of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
Luciano PinottiDepartment of Veterinary Medicine and Animal Science (DIVAS), University of Milan, Via dell'Università 6, 26900, Lodi, Italy.

Funding

Regione Lombardia D44I20002000002
6 · The paper itself

Abstract

Replacing cereals with food leftovers could reduce feed-food competition and keep nutrients and energy in the food chain. Former food products (FFPs) are industrial food leftovers no more intended for human but still suitable as alternative and sustainable feedstuffs for monogastric. In this study, omics approaches were applied to evaluate the impact of dietary FFPs on pig liver proteome and plasma peptidome. Thirty-six Swiss Large White male castrated pigs were randomly assigned to three dietary treatments [control (CTR), 30% CTR replaced with salty FFP (SA), 30% CTR replaced with sugary FFP (SU)] from the start of the growing phase (22.4 ± 1.7 kg) until slaughtering (110 ± 3 kg). The low number of differentially regulated proteins in each comparison matrix (SA/SU vs. CTR) and the lack of metabolic interaction indicated a marginal impact on hepatic lipid metabolism. The plasma peptidomics investigation showed low variability between the peptidome of the three dietary groups and identified three possible bioactive peptides in the SA group associated with anti-hypertension and vascular homeostasis regulation. To conclude, the limited modulation of liver proteome and plasma peptidome by the SA and SU diets strenghtened the idea of reusing FFPs as feed ingredients to make pig production more sustainable.

Indexed as

LiverAnimal FeedAnimalsMalePeptidesProteomeProteomicsSwinePeptidesProteomeFormer food productsLiverPeptidomicsPigsPlasmaProteomics

Identifiers

PMID39169123
PMCPMC11339069

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.