Evidence map›Paper›PMID 39169162›Full record

ArticleEMBO molecular medicine2024

Fertility protection during chemotherapy treatment by boosting the NAD(P)

Wing-Hong Jonathan Ho, Maria B Marinova, Dave R Listijono, Michael J Bertoldo, Dulama Richani, Lynn-Jee Kim, Amelia Brown, Angelique H Riepsamen, Safaa Cabot, Emily R Frost and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Oxidative Stress andInternational journal of molecular sciences · 2026
    Review
  2. Review
  3. Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
  5. Oocyte development: it's all about quality.Reproductive biomedicine online · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Wing-Hong Jonathan Ho *School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Maria B Marinova *School of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Dave R ListijonoSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Michael J BertoldoSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Dulama RichaniSchool of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.
Lynn-Jee KimSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Amelia BrownSchool of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.
Angelique H RiepsamenSchool of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.
Safaa CabotSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Emily R FrostSchool of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.ORCID http://orcid.org/0000-0001-8696-2136
Sonia BustamanteBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Kensington, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-5411-2919
Ling ZhongBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Kensington, NSW, 2052, Australia.
Kaisa SelesniemiPaul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA.
Derek WongSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Romanthi MadawalaSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Maria MarchanteIVI Foundation, Valencia, Spain.ORCID http://orcid.org/0009-0006-7560-6076
Dale M GossSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Catherine LiSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
Toshiyuki ArakiDepartment of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8502, Japan.ORCID http://orcid.org/0000-0003-3625-2042
David J LivingstonMetro International Biotech, Worcester, MA, USA.
Nigel TurnerSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia.
David A SinclairPaul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9936-436X
Kirsty A WaltersSchool of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.
Hayden A HomerSchool of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-3104-0449
Robert B GilchristSchool of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.ORCID http://orcid.org/0000-0003-1611-7142
Lindsay E WuSchool of Biomedical Sciences, UNSW Sydney, Kensington, NSW, 2052, Australia. lindsay.wu@unsw.edu.au.ORCID http://orcid.org/0000-0002-1599-7574

Funding

American Federation for Aging Research (AFAR) Hevolution New Investigator Award in Aging BiologyDHAC | National Health and Medical Research Council (NHMRC) APP1103689DHAC | National Health and Medical Research Council (NHMRC) APP1117538DHAC | National Health and Medical Research Council (NHMRC) APP1122484DHAC | National Health and Medical Research Council (NHMRC) APP1127821DHAC | National Health and Medical Research Council (NHMRC) APP1139763DHAC | National Health and Medical Research Council (NHMRC) APP2009940
6 · The paper itself

Abstract

Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to maintain ovarian function are urgently needed. Given the role of reduced nicotinamide adenine dinucleotide phosphate (NADPH) as an essential cofactor for drug detoxification, we sought to test whether boosting the NAD(P)

Indexed as

Antineoplastic AgentsMetabolomeAnimalsCell Line, TumorDisease Models, AnimalFemaleFertilityHumansInfertility, FemaleMiceNADNADPNicotinamide MononucleotideOvaryAntineoplastic AgentsNADNADPNicotinamide MononucleotideInfertilityNicotinamide Adenine Dinucleotide (NAD+)Nicotinamide Mononucleotide (NMN)OncofertilityOvarian Toxicity

Identifiers

PMID39169162
PMCPMC11473878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.