ArticleNature2024
Short-term post-fast refeeding enhances intestinal stemness via polyamines.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- IBD-related inflammatory memory and colorectal cancer: epigenetic mechanisms and microbiome interventions.Frontiers in immunology · 2026Pooled it
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
- Dietary Regulation of Intestinal Stem Cell Function: Nutrient-Sensing, Microbiota-Mediated, and Regenerative Mechanisms from a Dietetic Perspective.Biomedicines · 2026Review
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- Comprehensive metabolic characterization of pediatric ependymomas.Life metabolism · 2026Article
- Article
- High ambient temperature activates a neural circuit for gut glucose uptake in male mice.Nature communications · 2026Article
- The Impact of the Exposome on Epithelial Barriers: New Approach Methodologies for Translational Research.Thoracic research and practice · 2026Article
- A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- Epigenetic memory of colitis promotes tumour growth.Nature · 2026Article
- O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells.bioRxiv : the preprint server for biology · 2026Article
- Article
- Paligenosis: dual potential of mature cell plasticity in regeneration and tumorigenesis.MedScience · 2026Review
- Glucose availability tunes latent CD8+ T cell expansion potential through a mitogen-independent, mTOR-dependent regulatory switch.bioRxiv : the preprint server for biology · 2026Article
- Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress.International journal of biological sciences · 2026Article
- Competitive Binding of UBA52 and HOPX Modulates β-catenin Stability in Colorectal Cancer in the Context of High-Iron Intake.International journal of biological sciences · 2026Article
- Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.Frontiers in immunology · 2026Review
- Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness.Nature aging · 2026Article
- Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation.Development, growth & differentiation · 2026Review
- Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation.Nature communications · 2025Article
Corrections and comments
- Update of
Authors and funding
26 authors.
Shinya Imada *Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Saleh Khawaled *Department of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Heaji ShinDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0001-5208-5999
Sven W MeckelmannApplied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.
Charles A WhittakerBarbara K. Ostrom (1978) Bioinformatics and Computing Core Facility, Swanson Biotechnology Center, Koch Institute at the MIT, Cambridge, MA, USA.ORCID 0000-0002-2400-0094
Renan Oliveira CorrêaDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0002-3333-0482
Chiara AlquatiDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0002-2003-3622
Yixin LuDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Guodong TieDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Dikshant PradhanBarbara K. Ostrom (1978) Bioinformatics and Computing Core Facility, Swanson Biotechnology Center, Koch Institute at the MIT, Cambridge, MA, USA.
Gizem Calibasi-KocalDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0002-3201-4752
Luiza Martins Nascentes MeloDepartment of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.ORCID 0000-0002-5980-5220
Gabriele AlliesDepartment of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.
Jonas RöslerDepartment of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.
Pia WittenhoferApplied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.
Jonathan KrystkiewiczDepartment of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany.
Oliver J SchmitzApplied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-2184-1207
Jatin RoperDivision of Gastroenterology, Department of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0002-8851-1352
Marco Aurelio Ramirez VinoloLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Luigi RicciardielloDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Evan C LienDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-7866-4761
Matthew G Vander HeidenDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0002-6702-4192
Ramesh A ShivdasaniDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-2828-1727
Chia-Wei ChengDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Alpaslan TasdoganDepartment of Dermatology, University Hospital Essen and German Cancer Consortium, Essen, Germany. alpaslan.tasdogan@uk-essen.de.ORCID 0000-0003-2543-852X
Ömer H YilmazDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA. ohyilmaz@mit.edu.ORCID 0000-0002-7577-4612
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9MUnderstanding and Improving Platinum Anticancer DrugsR01CA034992 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 1985 to 2018
$6.8MProject 2U54CA224068 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CORCORAN, RYAN BRUCE, FLAHERTY, KEITH T · 2017 to 2021
$6.3MTranscriptional control and enhancer recruitment in mouse and human intestinal secretory differentiationR01DK082889 · NIDDK · DANA-FARBER CANCER INST · PI Ramesh A Shivdasani · 2010 to 2026
$5.2MEffects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.R01CA257523 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STAPPENBECK, THADDEUS S · 2021 to 2025
$3.7MMechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunctionR01DK126545 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KLOVERPRIS, HENRIK, KWON, DOUGLAS · 2020 to 2024
$3.6MImmunometabolic regulation of CD8+ T cell mediated intestinal epithelial cell death in people with HIV (PWH)R01DK133919 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Douglas Kwon, Omer Yilmaz · 2022 to 2026
$3.5MDeveloping high-throughput genetic perturbation strategies for single cells in cancer organoidsU01CA250554 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BERGER, BONNIE, YILMAZ, OMER · 2020 to 2022
$2.8MDietary control of stem cells in physiology and cancerR01CA211184 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2017 to 2021
$2.0MWnt signaling in obesity-associated colorectal cancerR37CA259363 · NCI · DUKE UNIVERSITY · PI Jatin Roper · 2022 to 2026
$1.8MMICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEINR01DK126969 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2021 to 2024
$1.6MPROSPECT - Stem cell modelsOT2CA297570 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Omer Yilmaz · 2024 to 2026
$1.4MMedical Research Council MR/X020258/1NCI NIH HHS OT2 CA297570NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA034992NCI NIH HHS R01 CA211184NCI NIH HHS R01 CA257523NCI NIH HHS R37 CA259363NCI NIH HHS U01 CA250554NCI NIH HHS U54 CA224068NIDDK NIH HHS R00 DK123407NIDDK NIH HHS R01 DK082889NIDDK NIH HHS R01 DK126545NIDDK NIH HHS R01 DK126969NIDDK NIH HHS R01 DK133919
Abstract
For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans
Indexed as
CarcinogenesisColonFastingFeeding BehaviorIntestine, SmallPolyaminesStem CellsAdenomatous Polyposis Coli ProteinAnimalsCell ProliferationDietFemaleMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseLgr5 protein, mouseMechanistic Target of Rapamycin Complex 1PolyaminesReceptors, G-Protein-Coupled
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.