Evidence map›Paper›PMID 39170458›Full record

ArticleHeliyon2024

Khalid Alshaghdali, Munazzah Tasleem, Raja Rezgui, Talal Alharazi, Tolgahan Acar, Raed Fahad Aljerwan, Ahmed Altayyar, Samra Siddiqui, Mohd Saeed, Dharmendra Kumar Yadav and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khalid AlshaghdaliDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
Munazzah TasleemDepartment of Biochemistry, Jamia Hamdard, Delhi, India.
Raja RezguiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
Talal AlharaziDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
Tolgahan AcarDepartment of Physical Therapy, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
Raed Fahad AljerwanRegional Laboratory, Ministry of Health, Hail, Saudi Arabia.
Ahmed AltayyarRegional Laboratory, Ministry of Health, Hail, Saudi Arabia.
Samra SiddiquiDepartment of Health Service Management, College of Public Health and Health Informatics, University of Hail, Hail, Saudi Arabia.
Mohd SaeedDepartment of Biology, College of Sciences, University of Hail, Hail, Saudi Arabia.
Dharmendra Kumar YadavCollege of Pharmacy, Gachon University of Medicine and Science, Hambakmoeiro, Yeonsugu, Incheon City, 21924, South Korea.
Amir SaeedDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a prominent contributor to morbidity and mortality in developed nations, primarily attributable to vascular complications such as atherothrombosis occurring in the coronary arteries. Aldose reductase (ALR2), the main enzyme in the polyol pathway, catalyzes the conversion of glucose to sorbitol, leading to a significant buildup of reactive oxygen species in different tissues. It is therefore a prime candidate for therapeutic targeting, and extensive study is currently underway to discover novel natural compounds that can inhibit it.

Indexed as

ADMETAldose reductase (ALR2)Cucumis meloDockingMD simulation

Identifiers

PMID39170458
PMCPMC11336452

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.