Evidence map›Paper›PMID 39172783›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca

Ame Xiong, Janet E Richmond, Hongkyun Kim

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ame XiongDiscipline of Cell Biology & Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064.ORCID 0000-0003-2365-5061
Janet E RichmondDepartment of Biological Sciences, University of Illinois, Chicago, IL 60607.
Hongkyun KimDiscipline of Cell Biology & Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064.ORCID 0000-0002-4879-7122

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Homeostatic regulation of CaV2 voltage-gated calcium channels at synapsesR21NS139113 · NINDS · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI KIM, HONGKYUN · 2024 to 2024
$434k
The role of mitochondrial stress response in alcohol-mediated neurotoxicityR21AA029811 · NIAAA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI KIM, HONGKYUN · 2022 to 2023
$410k
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21NS139113HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) R21AA029811NIAAA NIH HHS R21 AA029811NIH HHS P40 OD010440NINDS NIH HHS R21 NS139113
6 · The paper itself

Abstract

The abundance of CaV2 voltage-gated calcium channels is linked to presynaptic homeostatic plasticity (PHP), a process that recalibrates synaptic strength to maintain the stability of neural circuits. However, the molecular and cellular mechanisms governing PHP and CaV2 channels are not completely understood. Here, we uncover a previously not described form of PHP in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsNeurotransmitter AgentsAnimalsCalcium ChannelsCalcium Channels, N-TypeMembrane ProteinsMutationNeuronal PlasticityNeuronsPresynaptic TerminalsSynaptic TransmissionCaenorhabditis elegans ProteinsCalcium ChannelsCalcium Channels, N-TypeMembrane ProteinsNeurotransmitter Agentsunc-2 protein, C elegansactive zoneC. elegansdegradationP/Q type voltage-gated calcium channelpresynaptic homeostatic plasticity

Identifiers

PMID39172783
PMCPMC11363341

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.