Evidence map›Paper›PMID 39172786›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia.

Robin Bonomi, Ansel T Hillmer, Eric Woodcock, Shivani Bhatt, Aleksandra Rusowicz, Gustavo A Angarita, Richard E Carson, Margaret T Davis, Irina Esterlis, Nabeel Nabulsi and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  11. Reply to Pomara et al: A potential role for sTREM2 in PTSD?Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Microglia-mediated neuroimmune suppression in posttraumatic stress disorder.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Robin BonomiDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.ORCID 0000-0003-4500-944X
Ansel T HillmerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.ORCID 0000-0002-8105-1381
Eric WoodcockDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.ORCID 0000-0003-0070-7260
Shivani BhattDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.
Aleksandra RusowiczDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.
Gustavo A AngaritaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0002-9338-7966
Margaret T DavisDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.
Irina EsterlisDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.ORCID 0000-0001-6293-1458
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0001-8129-0051
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520.
John H KrystalDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.ORCID 0000-0001-6952-1726
Robert H PietrzakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.
Kelly P CosgroveDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06511.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Clinical Neuroscience Research Training Program in PsychiatryT32MH019961 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 1996 to 2026
$5.9M
Imaging Microglial Activation in PTSD with PETR01MH110674 · NIMH · YALE UNIVERSITY · PI COSGROVE, KELLY P., PIETRZAK, ROBERT H · 2017 to 2020
$3.1M
in vivo investigation of KOR as a marker of BPD and suicide related endophenotypesR01MH131720 · NIMH · YALE UNIVERSITY · PI DAVIS, MARGARET TAYLOR · 2023 to 2025
$2.3M
Multimodal Investigation of the Neuroimmune System in Opioid Use DisorderR00DA048125 · NIDA · WAYNE STATE UNIVERSITY · PI WOODCOCK, ERIC ANDREW · 2021 to 2023
$823k
Multimodal Investigation of the Neuroimmune System in Opioid Use DisorderK99DA048125 · NIDA · YALE UNIVERSITY · PI WOODCOCK, ERIC ANDREW · 2019 to 2020
$334k
HHS | NIH | National Institute of Mental Health (NIMH) 5T32MH019961-24HHS | NIH | National Institute of Mental Health (NIMH) R01MH110674NCATS NIH HHS UL1 TR001863NIDA NIH HHS K99 DA048125NIDA NIH HHS R00 DA048125NIMH NIH HHS R01 MH110674NIMH NIH HHS R01 MH131720NIMH NIH HHS T32 MH019961Yale University (Yale) Detre Award for Neuroscience
6 · The paper itself

Abstract

Dynamic brain immune function in individuals with posttraumatic stress disorder is rarely studied, despite evidence of peripheral immune dysfunction. Positron emission tomography brain imaging using the radiotracer [

Indexed as

AnhedoniaMicrogliaPositron-Emission TomographyReceptors, GABAStress Disorders, Post-TraumaticAdultBrainFemaleHumansLipopolysaccharidesMaleMiddle AgedNeuroimmunomodulationLipopolysaccharidesReceptors, GABATSPO protein, humanneuroimmunePETPTSDTSPO

Identifiers

PMID39172786
PMCPMC11363315

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.