Evidence map›Paper›PMID 39173103›Full record

Observational studyNeurology2024

Persistent Autonomic and Immunologic Abnormalities in Neurologic Post-Acute Sequelae of SARS-CoV2 Infection.

David S Goldstein, Yair Mina, Brian Walitt, Patti Sullivan, Yoshimi Enose-Akahata, Steven Jacobson, My-Le Nguyen, Stanislav Sidenko, Amanda Wiebold, Bryan Smith and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

David S GoldsteinFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.ORCID 0000-0002-5709-9940
Yair MinaFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.ORCID 0000-0003-2311-6623
Brian WalittFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.ORCID 0000-0003-1743-5230
Patti SullivanFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.
Yoshimi Enose-AkahataFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.ORCID 0000-0002-7102-9703
Steven JacobsonFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.ORCID 0000-0003-3127-1287
My-Le NguyenFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.
Stanislav SidenkoFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.
Amanda WieboldFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.
Bryan SmithFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.ORCID 0000-0001-9850-5944
Janna GelsominoFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.
Risa IsonakaFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.
Sarah MooreFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.
Avindra NathFrom the Autonomic Medicine Section (D.S.G., P.S., J.G., R.I., S.M.), and Infections of the Nervous System Section (Y.M., A.W., B.S.) Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD; Sackler Faculty of Medicine (Y.M.), Tel Aviv University, Israel; Office of the Clinical Director (B.W., A.N.), and Viral Immunology Section (Y.E.-A., S.J.), DIR, NINDS; and Echocardiography Laboratory (M.-L.N., S.S.), DIR, National Heart, Lung, and Blood Institute, Bethesda, MD.ORCID 0000-0003-0927-5855

Funding

Involvement Of Human Viruses Associated With Chronic Neurologic DiseaseZIANS002817 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2009 to 2025
$26.5M
Biomarkers of Parkinson Disease and Related DisordersZIANS003034 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2009 to 2025
$22.8M
Translational studies of human viruses and chronic neurologic diseaseZIANS003040 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI JACOBSON, STEVEN · 2009 to 2025
$10.1M
6 · The paper itself

Abstract

objectivesAfter acute coronavirus disease-2019 (COVID-19), people often experience fatigue, "brain fog," or other central neurologic symptoms (neuro-post-acute SARS-CoV2, or "Neuro-PASC"). In this observational study we evaluated whether abnormalities noted on initial evaluation persist after at least another year.

methodsNeuro-PASC research participants who had undergone comprehensive inpatient testing at the NIH Clinical Center returned after at least 1 year for follow-up assessments including symptoms rating scales, MRI, lumbar puncture for tests of the CSF, physiologic recordings during the Valsalva maneuver and head-up tilting (with serial plasma catechols and cardiac Doppler ultrasound during the tilting), blood volume measurement, skin biopsies to examine sympathetic innervation, and blood sampling for neuroendocrine and immunologic measures.

results7 patients with Neuro-PASC (6 women, age range 42-63 years) underwent follow-up testing. 71% of initially abnormal test results remained abnormal at follow-up, including the pattern of CSF and serum oligoclonal bands, CSF indices of central catecholamine deficiency, baroreflex-cardiovagal dysfunction, the occurrence of tilt-evoked sudden hypotension, white matter hyperintensities on MRI, and adaptive responses in CSF. DISCUSSION: In Neuro-PASC most of the autonomic and immunologic abnormalities found initially are still present after more than a year.

Indexed as

Autonomic Nervous System DiseasesPost-Acute COVID-19 SyndromeAdultCOVID-19FemaleFollow-Up StudiesHumansMaleMiddle AgedSARS-CoV-2Time Factors

Identifiers

PMID39173103
PMCPMC11343584

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.