Evidence mapPaperPMID 39173523Full record

Trial reportBehaviour research and therapy2024

A randomized clinical trial to evaluate feasibility, tolerability, and preliminary target engagement for a novel executive working memory training in adolescents with ADHD.

Abigail J Sullivan, Jacey Anderson, Morgan Beatty, Jimmy Choi, James Jaccard, Keith Hawkins, Godfrey Pearlson, Michael C Stevens

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Behaviour research and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abigail J SullivanOlin Neuropsychiatry Research Center, Hartford HealthCare, Hartford, CT, 06106, USA. Electronic address: abigail.sullivan@hhchealth.org.
Jacey AndersonOlin Neuropsychiatry Research Center, Hartford HealthCare, Hartford, CT, 06106, USA.
Morgan BeattyOlin Neuropsychiatry Research Center, Hartford HealthCare, Hartford, CT, 06106, USA.
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford HealthCare, Hartford, CT, 06106, USA.
James JaccardNew York University Silver School of Social Work, New York, NY, 10003, USA.
Keith HawkinsYale University School of Medicine, New Haven, CT, 06520, USA.
Godfrey PearlsonOlin Neuropsychiatry Research Center, Hartford HealthCare, Hartford, CT, 06106, USA; Yale University School of Medicine, New Haven, CT, 06520, USA.
Michael C StevensOlin Neuropsychiatry Research Center, Hartford HealthCare, Hartford, CT, 06106, USA; Yale University School of Medicine, New Haven, CT, 06520, USA.

Funding

Yale Clinical and Translational Science AwardUL1TR001863 · YALE UNIVERSITY · 2025 to 2025
$9.9M
Behavioral and Neural Target Engagement for ADHD Executive Working Memory TrainingR33MH122444 · NIMH · HARTFORD HOSPITAL · 2024 to 2025
$1.5M
Behavioral and Neural Target Engagement for ADHD Executive Working Memory TrainingR61MH122444 · NIMH · HARTFORD HOSPITAL · PI Michael C Stevens · 2022 to 2022
$726k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R33 MH122444NIMH NIH HHS R61 MH122444
6 · The paper itself

Abstract

objectiveWorking memory training for Attention-Deficit/Hyperactivity Disorder (ADHD) has focused on increasing working memory capacity, with inconclusive evidence for its effectiveness. Alternative training targets are executive working memory (EWM) processes that promote flexibility or bolster stability of working memory contents to guide behavior via selective attention. This randomized, placebo-controlled study was designed to assess feasibility, tolerability, and behavioral target engagement of a novel EWM training for ADHD.

method62 ADHD-diagnosed adolescents (12-18 years) were randomized to EWM training or placebo arms for 20 remotely coached sessions conducted over 4-5 weeks. Primary outcome measures were behavioral changes on EWM tasks. Secondary outcomes were intervention tolerability, trial retention, and responsiveness to adaptive training difficulty manipulations.

resultsLinear regression analyses found intervention participants showed medium effect size improvements, many of which were statistically significant, on Shifting and Filtering EWM task accuracy and Shifting and Updating reaction time measures. Intervention participants maintained strong self-rated motivation, mood, and engagement and progressed through the adaptive difficulty measures, which was further reflected in high trial retention.

conclusionsThe results suggest that these EWM processes show promise as training targets for ADHD. The subsequent NIMH R33-funded extension clinical trial will seek to replicate and extend these findings.

Indexed as

Attention Deficit Disorder with HyperactivityExecutive FunctionFeasibility StudiesMemory, Short-TermAdolescentChildCognitive Behavioral TherapyCognitive TrainingFemaleHumansMaleTreatment OutcomeAttention-deficit/hyperactivity disorder (ADHD)Clinical trialExecutive working memoryRandomized controlled trialTraining

Identifiers

PMID39173523
PMCPMC11465636

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.