Evidence map›Paper›PMID 39174449›Full record

Trial reportJournal of geriatric oncology2024

Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer.

Carolyn J Presley, Madison Grogan, Amy Compston, Karen Hock, Brittany Knauss, Elyse Redder, Nicole A Arrato, Stephen B Lo, Sarah Janse, Jason Benedict and 12 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Journal of geriatric oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04229381 (Resiliency Among Older Adults Receiving Lung Cancer Treatment), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04229381 nacompletednot on this map

Resiliency Among Older Adults Receiving Lung Cancer Treatment (ROAR-LCT): Physical Therapy and Progressive Muscle Relaxation in Improving Physical Performance and Mood in Older Patients With Stage IIIA-B or IV Lung Cancer Undergoing Treatment

TypeinterventionalSponsorOhio State University Comprehensive Cancer CenterRan2020 to 2022Enrolled18ConditionsAdvanced Lung Carcinoma, Extensive Stage Lung Small Cell Carcinoma, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8ArmsPhysical Therapy, Quality-of-Life Assessment, Questionnaire Administration, Relaxation Therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Carolyn J PresleyDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States; The Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Madison GroganDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States; The Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Amy CompstonThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Karen HockThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Brittany KnaussThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Elyse RedderThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Nicole A ArratoDepartment of Psychology, The Ohio State University, Columbus, OH, United States.
Stephen B LoDepartment of Psychology, The Ohio State University, Columbus, OH, United States.
Sarah JanseCenter for Biostatistics, The Ohio State University, Columbus, OH, United States.
Jason BenedictCenter for Biostatistics, The Ohio State University, Columbus, OH, United States.
Rebecca HoydDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States; The Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Nyelia WilliamsDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States; The Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States.
Scott HayesDepartment of Psychology, The Ohio State University, Columbus, OH, United States.
Sharla Wells-Di GregorioDivision of Palliative Medicine, Department of Internal Medicine, The Ohio State University Columbus, OH, United States.
Thomas M GillSection of Geriatric Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.
Heather AlloreSection of Geriatric Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States.
Brian FochtThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States; Division of Kinesiology, Department of Human Sciences, The Ohio State University, Columbus, OH, United States.
Morten QuistUniversity of Copenhagen, Copenhagen, Denmark.
David P CarboneDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States; The Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States; Pelotonia Institute for Immuno-Oncology, OSUCCC-James, The Ohio State University, Columbus, OH, United States.
Daniel SpakowiczDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States; The Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States; Pelotonia Institute for Immuno-Oncology, OSUCCC-James, The Ohio State University, Columbus, OH, United States.
Electra D PaskettThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States; Division of Cancer Control and Prevention, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Barbara L AndersenThe Ohio State University Comprehensive Cancer Center, James Cancer Hospital, & Solove Research Institute, Columbus, OH, United States; Department of Psychology, The Ohio State University, Columbus, OH, United States.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Amanda Ewart Toland · 1985 to 2026
$132.3M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Terri R. Fried · 2002 to 2026
$37.9M
Translational Training Grant in Experimental TherapeuticsK12CA133250 · NCI · OHIO STATE UNIVERSITY · PI WILLIAM E. CARSON, Rosa Lapalombella · 2008 to 2026
$15.0M
Resiliency among Older Adults Receiving Lung Cancer Treatment: A Supportive Care Intervention StudyK76AG074923 · NIA · OHIO STATE UNIVERSITY · PI PRESLEY, CAROLYN · 2021 to 2025
$1.2M
The microbiome in older adults with lung cancer: association of treatment regimens and diet with protective microbial profilesK01AG070310 · NIA · OHIO STATE UNIVERSITY · PI SPAKOWICZ, DANIEL J. · 2021 to 2025
$583k
Resiliency Among Older Adults Receiving Lung Cancer Treatment (ROAR-LCT): A Pilot Intervention StudyR03AG064374 · NIA · OHIO STATE UNIVERSITY · PI PRESLEY, CAROLYN · 2019 to 2020
$232k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K12 CA133250NCI NIH HHS P30 CA016058NIA NIH HHS K01 AG070310NIA NIH HHS K76 AG074923NIA NIH HHS P30 AG021342NIA NIH HHS R03 AG064374
6 · The paper itself

Abstract

introductionNovel supportive care interventions designed for an aging population with lung cancer are urgently needed. We aimed to determine the feasibility of a novel supportive care physical therapy (PT) plus progressive muscle relaxation (PMR) intervention delivered to older adults with advanced lung cancer in the United States (US). MATERIALS AND

methodsThis clinical trial, Resiliency Among Older Adults Receiving Lung Cancer Treatment (ROAR-LCT: NCT04229381), recruited adults aged ≥60 years with unresectable stage III/IV non-small cell (NSCLC) or small cell lung cancer (SCLC) receiving cancer treatment at The James Thoracic Oncology Center (planned enrollment, N = 20). There were no exclusion criteria pertaining to performance status, laboratory values, prior cancer diagnoses, comorbidities, or brain metastases. Participants were evaluated by PT and psychology and given an exercise pedaler, resistance bands, a relaxation voice recording, and instructions at study initiation. Participants were evaluated in-person by PTs and psychologists at the start and end of the 12-session intervention, with the intervening sessions conducted via virtual health. Participants completed self-reported measures of functional status, symptoms, and mood longitudinally with the following instruments: EQ-5D-5L, Patient Health Questionnaire-9, and General Anxiety Disorder-7. PT assessments included the Short Physical Performance Battery (SPPB) and the two-minute walk test. Feasibility was defined as at least 60% of participants completing at least 70% of all intervention sessions. Optional gut microbiome samples and activity monitoring data (ActiGraph®) were also collected.

resultsThe ROAR-LCT study concluded after consenting 22 patients. Among the 22 consented, 18 (81.8%) started the intervention; 11 participants (61.1%) completed at least 70% of all study sessions. All participants with SCLC completed the intervention. Reasons for withdrawal included progression of disease or hospitalization. The majority (88.9%) of patients who started were able to complete at least one virtual health session. Participants' functional status, SPPB, depression, and anxiety scores were stable from pre- to post-intervention. Participants who withdrew had worse baseline scores across domains. Seven microbiome and six ActiGraph® samples were collected. DISCUSSION: This is one of the first PT + PMR supportive care interventions using virtual health among older adults with advanced lung cancer to achieve feasibility in the US.

Indexed as

Carcinoma, Non-Small-Cell LungFeasibility StudiesLung NeoplasmsResilience, PsychologicalAgedAged, 80 and overAnxietyDepressionFemaleFunctional StatusHumansMaleMiddle AgedPhysical Therapy ModalitiesQuality of LifeRelaxation TherapyFunctional resiliencyFunctional statusLung cancerOlder adultsPhysical therapyProgressive muscle relaxationSupportive care intervention

Identifiers

PMID39174449
PMCPMC11701799

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.