Evidence map›Paper›PMID 39174768›Full record

ReviewNature metabolism2024

Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axis.

Elizabeth Schneider, Kenneth J O'Riordan, Gerard Clarke, John F Cryan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  3. The effects ofFrontiers in nutrition · 2025
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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth SchneiderAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Kenneth J O'RiordanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Gerard ClarkeAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0001-9771-3979
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland. j.cryan@ucc.ie.ORCID http://orcid.org/0000-0001-5887-2723

Funding

Science Foundation Ireland (SFI) SFI/12/RC/2273_P2
6 · The paper itself

Abstract

The prevalence of brain disorders, including stress-related neuropsychiatric disorders and conditions with cognitive dysfunction, is rising. Poor dietary habits contribute substantially to this accelerating trend. Conversely, healthy dietary intake supports mood and cognitive performance. Recently, the communication between the microorganisms within the gastrointestinal tract and the brain along the gut-brain axis has gained prominence as a potential tractable target to modulate brain health. The composition and function of the gut microbiota is robustly influenced by dietary factors to alter gut-brain signalling. To reflect this interconnection between diet, gut microbiota and brain functioning, we propose that a diet-microbiota-gut-brain axis exists that underpins health and well-being. In this Review, we provide a comprehensive overview of the interplay between diet and gut microbiota composition and function and the implications for cognition and emotional functioning. Important diet-induced effects on the gut microbiota for the development, prevention and maintenance of neuropsychiatric disorders are described. The diet-microbiota-gut-brain axis represents an uncharted frontier for brain health diagnostics and therapeutics across the lifespan.

Indexed as

BrainBrain-Gut AxisDietGastrointestinal MicrobiomeAnimalsCognitionHumans

Identifiers

PMID39174768

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.