Evidence map›Paper›PMID 39174865›Full record

ArticleCell biochemistry and biophysics2024

Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE

Hao-Ran Zhao, Qin-Chi Xian, Xuan-Ming Zhang, Xiao-Yu Ma, Fu-Qiao Wang, Rui-Si Wang, Zhi-Jie Liu, Zhi-Gang Zhang

Abstract read
In one paragraph

Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao-Ran Zhao *First Affiliated Hospital of Shihezi University, Shihezi, 832000, China.
Qin-Chi Xian *First Affiliated Hospital of Shihezi University, Shihezi, 832000, China.
Xuan-Ming ZhangFirst Affiliated Hospital of Shihezi University, Shihezi, 832000, China. haoxin0431@163.com.
Xiao-Yu MaFirst Affiliated Hospital of Shihezi University, Shihezi, 832000, China.
Fu-Qiao WangFirst Affiliated Hospital of Shihezi University, Shihezi, 832000, China.
Rui-Si WangFirst Affiliated Hospital of Shihezi University, Shihezi, 832000, China.
Zhi-Jie LiuFirst Affiliated Hospital of Shihezi University, Shihezi, 832000, China.
Zhi-Gang ZhangFirst Affiliated Hospital of Shihezi University, Shihezi, 832000, China. 912586487@qq.com.

Funding

National Administration of Traditional Chinese Medicine young Qhuang scholars support project (2020)218National Natural Science Foundation Project 81960853Shihezi University project ZZZC2023066Xinjiang Corps key areas of science and technology project 2023AB046
6 · The paper itself

Abstract

This study established an LPS-induced RAW264.7 macrophage inflammatory injury model and an AS mouse vulnerable plaque model to observe the effect of JPHYP on macrophage inflammation, plaque formation, blood lipids, inflammation levels, intestinal flora and the influence of TLR4/MyD88/MAPK pathway, and explore the anti-AS effect and molecular mechanism of JPHYP, and detected 16S rRNA of mice intestinal microbes. The difference of intestinal flora in different groups of mice was compared to further explore the intervention effect of JPHYP and clarify the molecular biological mechanism of JPHYP in preventing and treating AS by regulating TLR4/MyD88/MAPK inflammatory signaling pathway and improving intestinal flora.

Indexed as

Apolipoproteins EAtherosclerosisDrugs, Chinese HerbalGastrointestinal MicrobiomeInflammationMyeloid Differentiation Factor 88Toll-Like Receptor 4AnimalsDisease Models, AnimalLipopolysaccharidesMacrophagesMaleMiceMice, KnockoutRAW 264.7 CellsSignal TransductionApolipoproteins EDrugs, Chinese HerbalLipopolysaccharidesMyd88 protein, mouseMyeloid Differentiation Factor 88Tlr4 protein, mouseToll-Like Receptor 4AtherosclerosisInflammationIntestinal floraJianpi Huayu PrescriptionTLR4/MyD88/MAPK signal path

Identifiers

PMID39174865
PMCPMC11445337

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.