Evidence mapPaperPMID 39174895Full record

ReviewZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2024

Mechanism of salidroside in tumor suppression through the miRNA-mRNA signaling axis.

Xiaoxiong Wu, Zhendong Zhang, Xiaoping Wang

Abstract readReview
In one paragraph

Review in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaoxiong WuKey Laboratory of High Altitude Hypoxia Environment and Life Health; Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Xizang Materia Medica of Xizang Medical Research Center of Xizang; School of Medicine, Xizang Minzu University, Xianyang Shaanxi 712082, China. 3263439881@qq.com.
Zhendong ZhangKey Laboratory of High Altitude Hypoxia Environment and Life Health; Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Xizang Materia Medica of Xizang Medical Research Center of Xizang; School of Medicine, Xizang Minzu University, Xianyang Shaanxi 712082, China.
Xiaoping WangKey Laboratory of High Altitude Hypoxia Environment and Life Health; Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Xizang Materia Medica of Xizang Medical Research Center of Xizang; School of Medicine, Xizang Minzu University, Xianyang Shaanxi 712082, China. xpwang@xzmu.edu.cn.

Funding

the Natural Science Foundation of Shaanxi Province 2020JM-590 and 2022JM-465the Research Project of Chunhui Plan of Ministry of Education 202070310
6 · The paper itself

Abstract

With the rapid development of traditional Chinese medicine and the continuous discovery of various anticancer effects of salidroside (sal), it is known that sal inhibits tumor proliferation, invasion and migration by inducing apoptosis and autophagy, regulating the cell cycle, modulating the tumor microenvironment, and controlling cancer-related signaling pathways and molecules. The microRNA (miRNA)-mRNA signaling axis can regulate the expression of target mRNAs by altering miRNA expression, thereby affecting the growth cycle, proliferation, and metabolism of cancer cells. Studies have shown that sal can influence the occurrence and progression of various malignant tumors through the miRNA-mRNA signaling axis, inhibiting the progression of lung cancer, gastric cancer, and nasopharyngeal carcinoma, with a notable time and dose dependence in its antitumor effects. Summarizing the specific mechanism of sal regulating miRNA-mRNA signaling axis to inhibit tumors in recent years can provide a new theoretical basis, diagnosis, and therapeutic methods for the research on prevention and treatment of tumors.

Indexed as

GlucosidesMicroRNAsPhenolsRNA, MessengerSignal TransductionAnimalsAntineoplastic Agents, PhytogenicApoptosisCell ProliferationGene Expression Regulation, NeoplasticHumansLung NeoplasmsNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplasmsStomach NeoplasmsAntineoplastic Agents, PhytogenicGlucosidesMicroRNAsPhenolsrhodiolosideRNA, MessengermicroRNAmRNAsalidrosidesignaling pathwaytumor

Identifiers

PMID39174895
PMCPMC11341224

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.