Evidence map›Paper›PMID 39175614›Full record

ArticleFrontiers in physiology2024

Repeated seizure-induced brainstem neuroinflammation contributes to post-ictal ventilatory control dysfunction.

Wasif A Osmani, Alexander Gallo, Madeline Tabor, Melissa Eilbes, Denise R Cook-Snyder, Matthew R Hodges

Abstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wasif A OsmaniDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Alexander GalloDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Madeline TaborDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Melissa EilbesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Denise R Cook-SnyderDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.

Funding

Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Investigating the role of brainstem neuroinflammation in cardiorespiratory control in a rat model of recurrent epilepsyF30HL160122 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI OSMANI, WASIF A · 2022 to 2024
$150k
NHLBI NIH HHS F30 HL160122NHLBI NIH HHS R01 HL122358
6 · The paper itself

Abstract

Patients with epilepsy face heightened risk of post-ictal cardiorespiratory suppression and sudden unexpected death in epilepsy (SUDEP). Studies have shown that neuroinflammation, mediated by the activation of microglia and astrocytes, may be a cause or consequence of seizure disorders. Kcnj16 (Kir5.1) knockout rats (SS

Indexed as

brainstemneuroinflammationpre-Bötzinger complexrepeated seizuresventilatory control

Identifiers

PMID39175614
PMCPMC11339535

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.