Evidence map›Paper›PMID 39177202›Full record

ArticleAutophagy2025

Myotubularin 2 interacts with SEC23A and negatively regulates autophagy at ER exit sites in Arabidopsis.

Xinjing Li, Jing Zheng, Jing Su, Lin Wang, Lin Luan, Taotao Wang, Fang Bai, Qing Zhong, Qingqiu Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinjing LiState Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, P. R. China.
Jing ZhengDepartment of Plant Biology and Ecology, College of Life Sciences, Nankai University, Tianjin, P. R. China.
Jing SuDepartment of Plant Biology and Ecology, College of Life Sciences, Nankai University, Tianjin, P. R. China.
Lin WangShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, P. R. China.
Lin LuanDepartment of Plant Biology and Ecology, College of Life Sciences, Nankai University, Tianjin, P. R. China.
Taotao WangState Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, P. R. China.
Fang BaiShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, P. R. China.
Qing ZhongKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Qingqiu GongState Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, P. R. China.ORCID 0000-0002-9803-8554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Starvation- or stress-induced phosphatidylinositol 3-phosphate (PtdIns3P/PI3P) production at the endoplasmic reticulum (ER) subdomains organizes phagophore assembly and autophagosome formation. Coat protein complex II (COPII) vesicles budding from ER exit site (ERES) also contribute to autophagosome formation. Whether any PtdIns3P phosphatase functions at ERES to inhibit macroautophagy/autophagy is unknown. Here we report Myotubularin 2 (MTM2) of Arabidopsis as a PtdIns3P phosphatase that localizes to ERES and negatively regulates autophagy. MTM2 binds PtdIns3P with its PH-GRAM domain

Indexed as

ArabidopsisArabidopsis ProteinsAutophagyEndoplasmic ReticulumPhosphatidylinositol PhosphatesProtein Tyrosine Phosphatases, Non-ReceptorAutophagosomesCOP-Coated VesiclesProtein BindingVesicular Transport ProteinsArabidopsis Proteinsmyotubularinphosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesProtein Tyrosine Phosphatases, Non-ReceptorVesicular Transport ProteinsAutophagyCOPIIER exit sitemyotubularinPtdIns3Psalt stress

Identifiers

PMID39177202
PMCPMC11702955

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.