Evidence map›Paper›PMID 39178246›Full record

ArticlePloS one2024

In vivo pharmacokinetics of ginsenoside compound K mediated by gut microbiota.

Ming-Si Deng, Su-Tian-Zi Huang, Ya-Ni Xu, Li Shao, Zheng-Guang Wang, Liang-Jian Chen, Wei-Hua Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ming-Si DengDepartment of Stomatology, the Third Xiangya Hospital of Central South University, Central South University, Changsha, China.
Su-Tian-Zi HuangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Ya-Ni XuDepartment of Orthodontics, Changsha Stomatological Hospital, Hunan University of Chinese Medicine, Changsha, China.
Li ShaoDepartment of Pharmacognosy, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Zheng-Guang WangDepartment of Spinal Surgery, the Third Xiangya Hospital of Central South University, Central South University, Changsha, China.ORCID 0000-0001-8760-068X
Liang-Jian ChenDepartment of Stomatology, the Third Xiangya Hospital of Central South University, Central South University, Changsha, China.
Wei-Hua HuangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ginsenoside Compound K (GCK) is the main metabolite of natural protopanaxadiol ginsenosides with diverse pharmacological effects. Gut microbiota contributes to the biotransformation of GCK, while the effect of gut microbiota on the pharmacokinetics of GCK in vivo remains unclear. To illustrate the role of gut microbiota in GCK metabolism in vivo, a systematic investigation of the pharmacokinetics of GCK in specific pathogen free (SPF) and pseudo-germ-free (pseudo-GF) rats were conducted. Pseudo-GF rats were treated with non-absorbable antibiotics. Liquid chromatography tandem mass spectrometry (LC-MS/MS) was validated for the quantification of GCK in rat plasma. Compared with SPF rats, the plasma concentration of GCK significantly increased after the gut microbiota depleted. The results showed that GCK absorption slowed down, Tmax delayed by 3.5 h, AUC0-11 increased by 1.3 times, CLz/F decreased by 0.6 times in pseudo-GF rats, and Cmax was 1.6 times higher than that of normal rats. The data indicated that gut microbiota played an important role in the pharmacokinetics of GCK in vivo.

Indexed as

Gastrointestinal MicrobiomeGinsenosidesAnimalsChromatography, LiquidMaleRatsRats, Sprague-DawleySpecific Pathogen-Free OrganismsTandem Mass Spectrometryginsenoside compound KGinsenosides

Identifiers

PMID39178246
PMCPMC11343376

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.