ArticleScientific reports2024
Glycated haemoglobin index is a new predictor for all-cause mortality and cardiovascular mortality in the adults.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Hemoglobin glycation index correlates with the prognoses of critically ill patients with hyperlipidemia: a retrospective cohort study from the MIMIC-IV database.BMC endocrine disorders · 2026Article
- Hemoglobin glycation index and renal progression in patients with type 2 diabetes: a 5-year cohort study.Endocrine · 2026Article
- Comparative Evaluation of Metabolic Syndrome, Circadian Syndrome, and Allostatic Load Measures on All-Cause Mortality in U.S. Males and Females.International journal of endocrinology · 2026Article
- Association between hemoglobin glycation index and cognitive function: Evidence in the elderly.PloS one · 2026Article
- Association of hemoglobin glycation index with the severity and mortality of cardiovascular-kidney-metabolic syndrome: a population-based cohort study.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Hemoglobin glycation index and mortality in chronic heart failure: A retrospective cohort study.Medicine · 2025Observational
- Relationship between hemoglobin glycation index and all-cause mortality in patients with acute myocardial infarction: based on MIMIC-IV database.Diabetology & metabolic syndrome · 2025Article
- Association between hemoglobin glycation index and mortality in surgical ICU patients.Scientific reports · 2025Article
- The GMI/HbA1c ratio does not independently predict diabetic retinopathy in adults with Type 1 Diabetes.Scientific reports · 2025Observational
- Association of Hemoglobin Glycation Index With All-Cause Mortality, Cardiac Mortality, and Cardiovascular Mortality in the General Population: A Retrospective Cohort Study of NHANES Data.Reviews in cardiovascular medicine · 2025Article
- Delving into biomarkers and predictive modeling for CVD mortality: a 20-year cohort study.Scientific reports · 2025Article
- Comparative prognostic value of hemoglobin glycation index and glycation gap for mortality risk in adults: A population-based study.Diabetes & vascular disease researchArticle
- Association of the hemoglobin glycation index with the large-artery atherosclerosis subtype in ischemic stroke: a dual-cohort study.Frontiers in neurologyArticle
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4 authors.
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Abstract
Glycosylated haemoglobin index (HGI) has been shown to correlate with the prognosis of metabolic diseases, but the relationship with mortality remains unclear. This study included 18,285 US adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. During the median follow-up period of 115 months, a total of 2572 all-cause deaths and 671 cardiovascular disease (CVD) deaths occurred. The restricted cubic spline revealed a U-shaped correlation between HGI and all-cause and CVD mortality. After adjusting for all covariates, the optimal inflection point values in all-cause and CVD deaths were 0.17 and 0.02, respectively. In the left side of the inflection point, the risk of all-cause mortality and CVD mortality decreased by approximately 24% (HR 0.76, 95% CI 0.69, 0.84) and 25% (HR 0.75, 95% CI 0.60, 0.96) with the increase in HGI. Conversely, in the right of the inflection point, an increase of 1 unit in the HGI was linked with a 17% (HR 1.17, 95% CI 1.07, 1.27) and 31% (HR 1.31, 95% CI 1.15, 1.49) increase in all-cause and CVD mortality. Our study showed that HGI is an important tool for predicting the risk of all-cause mortality and CVD death in US adults and there is a U-shaped relationship between HGI and mortality.
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