Evidence map›Paper›PMID 39179631›Full record

ArticleScientific reports2024

LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia.

Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryuichi OhgakiDepartment of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ohgaki@pharma1.med.osaka-u.ac.jp.
Yuma HiraseDepartment of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Minhui XuDepartment of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Hiroki OkanishiDepartment of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yoshikatsu KanaiDepartment of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ykanai@pharma1.med.osaka-u.ac.jp.

Funding

Japan Agency for Medical Research and Development JP20cm0106151Japan Society for the Promotion of Science 22H02809Japan Society for the Promotion of Science 22K06856
6 · The paper itself

Abstract

L-type amino acid transporter 1 (LAT1) is upregulated in various cancer types and contributes to disease progression. Previous studies have demonstrated or suggested that hypoxia-inducible factors (HIFs), the key transcription factors in hypoxic responses, control the expression of LAT1 gene in several types of cancer cells. However, this regulatory relationship has not been investigated yet in colorectal cancer (CRC), one of the cancer types in which the increased LAT1 expression holds prognostic significance. In this study, we found that neither LAT1 mRNA nor protein is induced under hypoxic condition (1% O

Indexed as

Basic Helix-Loop-Helix ProteinsColorectal NeoplasmsGene Expression Regulation, NeoplasticHypoxia-Inducible Factor 1, alpha SubunitLarge Neutral Amino Acid-Transporter 1Cell HypoxiaCell Line, TumorEndothelial PAS Domain-Containing Protein 1Glucose Transporter Type 1HT29 CellsHumansRNA, MessengerUp-RegulationVon Hippel-Lindau Tumor Suppressor ProteinBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Glucose Transporter Type 1HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitLarge Neutral Amino Acid-Transporter 1RNA, MessengerSLC7A5 protein, humanVon Hippel-Lindau Tumor Suppressor ProteinAmino acid transporterColorectal cancerHypoxiaHypoxia-inducible factorLAT1Transcriptional regulation

Identifiers

PMID39179631
PMCPMC11343765

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.