Evidence map›Paper›PMID 39180118›Full record

ArticleHereditary cancer in clinical practice2024

Possible link between familial susceptibility to cancer and the level of oxidative stress in thyroid cancer patients.

Ivane Javakhishvili, Kote Mardaleishvili, Maka Buleishvili, Maia Mantskava, Irakli Chkhikvishvili, Sophio Kalmakhelidze, Nina Kipiani, Tamar Sanikidze

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditary cancer in clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ivane JavakhishviliTbilisi State Medical University, Tbilisi, Georgia.
Kote MardaleishviliTbilisi State Medical University, Tbilisi, Georgia.
Maka BuleishviliDepartment of Physics, Biophysics, Biomechanics and Informative Technologies of Tbilisi, State Medical University, Tbilisi, Georgia.
Maia MantskavaBeritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
Irakli ChkhikvishviliTbilisi State Medical University, Tbilisi, Georgia.
Sophio KalmakhelidzeBeritashvili Center of Experimental Biomedicine, Tbilisi State Medical University, Tbilisi, Georgia.
Nina KipianiBeritashvili Center of Experimental Biomedicine, Tbilisi State Medical University, Tbilisi, Georgia.
Tamar SanikidzeDepartment of Physics, Biophysics, Biomechanics and Informative Technologies of Tbilisi, State Medical University, Tbilisi, Georgia. tsanikidze@tsmu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHereditary cancer is estimated to account for up to 10% of the worldwide cancer burden; 5% of all thyroid cancers are thought to be genetic. Inheritance of a deleterious mutation in genes associated with a high lifetime risk of developing cancer. Cancer-predisposing genes can promote the initiation and progression of thyroid cancer by enhancing the activation of major signaling pathways through oxidative stress mechanisms.

aimIdentification of the possible link between familial susceptibility to cancer and the level of oxidative stress in thyroid cancer patients.

methodsPatients with thyroid cancer (with and without genetic predisposition) were investigated. Study participants were treated in Limited Liability Company (LLC) "Oncology Scientific Research Center" (Tbilisi, Georgia). The study group was collected between 2020 and 2021. In patients' blood, the thyroid hormones content (free Triiodothyronine (fFT3), free Thyroxine (fFT4), bound Triiodothyronine (FT3), bound Thyroxine (FT4), Thyroid-stimulating hormone (TSH)), and oxidative stress intensity (total activity of non-enzymatic antioxidant system (TAA) and the lipid peroxidation product, malondialdehyde (MDA), content) were investigated.

resultsThe difference in free and bound forms of T3 and T4 levels in the blood serum between patients with thyroid cancer (Group 2 and Group 3) and the control group (Group 1) was not statistically significant (F

Identifiers

PMID39180118
PMCPMC11342469

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.