Evidence map›Paper›PMID 39180500›Full record

ArticleCell proliferation2025

A novel tetrahedral framework nucleic acid-derived chemodynamic therapy agent for effective glioblastoma treatment.

Xiaodie Li, Lei Li, Xin Fu, Shiqian Huang, Yuhao Wang, Yuepeng Yang, Shuqin Zhou, Zhaowei Zou, Qing Peng, Chao Zhang

Abstract read
In one paragraph

Article in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaodie LiDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Lei LiDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xin FuDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shiqian HuangClinical Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yuhao WangDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yuepeng YangDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shuqin ZhouDepartment of Anesthesiology of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, China.
Zhaowei ZouDepartment of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Qing PengCentral Laboratory of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, China.
Chao ZhangDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0007-8405-2164

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515110845Guangdong Basic and Applied Basic Research Foundation 2023A1515011042Science and Technology Program of Guangzhou 2023A04J0060the National Natural Science Foundation of China 22304072the National Natural Science Foundation of China 82373393
6 · The paper itself

Abstract

Chemodynamic therapy (CDT) has garnered significant attention for treating diverse malignant tumours due to its minimally invasive nature, reduced damage to healthy tissues, and potential mitigation of side effects. However, its application in glioblastoma (GBM) is hindered by the diminished capacity of CDT agents to traverse the blood-brain barrier (BBB), inadequate tumour targeting efficiency, and restricted availability of H

Indexed as

GlioblastomaHydrogen PeroxideNucleic AcidsAnimalsAntineoplastic AgentsBlood-Brain BarrierBrain NeoplasmsCell Line, TumorHumansIronMicePeptidesTriazolesTumor MicroenvironmentAngiopep-2Antineoplastic AgentsHydrogen PeroxideIronNucleic AcidsPeptidesTriazoles

Identifiers

PMID39180500
PMCPMC11693534

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.