Evidence map›Paper›PMID 39180695›Full record

ArticleMolecular neurobiology2025

Role of Lactobacillus plantarum-Derived Extracellular Vesicles in Regulating Alcohol Consumption.

Lulu Xu, Junwei Xiong, Xinxin Li, Jiajia Wang, Pengyu Wang, Xiaobin Wu, Jiaxi Wang, Yong Liu, Ran Guo, Xiaohe Fan and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lulu Xu *Department of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China.
Junwei Xiong *Department of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China.
Xinxin Li *Heilongjiang Province Key Laboratory of Mechanism and Prevention of Substance Dependence Disease, Mudanjiang, 157011, China.
Jiajia WangDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China.
Pengyu WangDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China.
Xiaobin WuDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China.
Jiaxi WangDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China.
Yong LiuHeilongjiang Province Key Laboratory of Mechanism and Prevention of Substance Dependence Disease, Mudanjiang, 157011, China.
Ran GuoDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China.
Xiaohe FanHeilongjiang Province Key Laboratory of Mechanism and Prevention of Substance Dependence Disease, Mudanjiang, 157011, China.
Xiaofeng ZhuDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China. zhuxiaofeng1227@163.com.
Yanzhong GuanDepartment of Physiology & Neurobiology, Mudanjiang Medical University, Mudanjiang, 157011, China. guanyanz@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol Use Disorder (AUD), characterized by repeated alcohol consumption and withdrawal symptoms, poses a significant public health issue. Alcohol-induced impairment of the intestinal barrier results in alterations in intestinal permeability and the composition of the intestinal microbiota. Such alterations lead to a reduced relative abundance of intestinal lactic acid bacteria. However, the role of gut microbiota in alcohol consumption is not yet fully understood. In this study, we explore the mechanism by which gut microbiota regulates alcohol consumption, specifically using extracellular vesicles derived from Lactobacillus plantarum (L-EVs). L-EVs were administered to Sprague-Dawley rats either through intraperitoneal injection or microinjection into the ventral tegmental area (VTA), resulting in a significant reduction in alcohol consumption 72 hours after withdrawal. The observed reduction was akin to the effect of an intra-VTA microinjection of Brain-Derived Neurotrophic Factor (BDNF). Intriguingly, the microinjection of K252a (a Trk B antagonist) into the VTA blocked the reducing effect of L-EVs on alcohol consumption. The intraperitoneal injection of L-EVs restored the diminished BDNF expression in the VTA of alcohol-dependent rats. Furthermore, L-EVs rescued the low BDNF expression in alcohol-incubated PC12 cells. In conclusion, our study demonstrates that L-EVs attenuated alcohol consumption by enhancing BDNF expression in alcohol-dependent rats, thus suggesting the significant therapeutic potential of L-EVs in preventing excessive alcohol consumption.

Indexed as

Alcohol DrinkingExtracellular VesiclesLactiplantibacillus plantarumAnimalsBrain-Derived Neurotrophic FactorEthanolMalePC12 CellsRatsRats, Sprague-DawleyVentral Tegmental AreaBrain-Derived Neurotrophic FactorEthanolAlcohol consumptionGut microbiotaLactobacillus plantarum-derived extracellular vesicles (L-EVs)Ventral tegmental area (VTA)

Identifiers

PMID39180695

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.