Evidence map›Paper›PMID 39181206›Full record

Observational studyThe American journal of clinical nutrition2024

The role of nutritional factors in transitioning between early, mid, and late stages of age-related macular degeneration: prospective longitudinal analysis.

Johanna M Seddon, Dikha De, Bernard Rosner

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00594672 (Age-Related Eye Disease Study), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00594672 active not recruitingnot on this map

Age-Related Eye Disease Study (AREDS) and AREDS2 Follow-Up

TypeobservationalSponsorNational Eye Institute (NEI)Ran2008Enrolled110ConditionsAge-Related Macular Degeneration, Cataract
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. An siRNA targetingMolecular therapy. Nucleic acids · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Johanna M SeddonDepartment of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States. Electronic address: johanna_seddon@yahoo.com.
Dikha DeDepartment of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Bernard RosnerChanning Division of Network Medicine, Department of Medicine, Harvard Medical School, Boston, MA, United States.

Funding

Etiologic Studies of Age-Related Macular DegenerationR01EY011309 · MASSACHUSETTS EYE AND EAR INFIRMARY · 2003 to 2005
$1.9M
Use of Correlated Data Methods in OphthalmologyR01EY022445 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · 2023 to 2025
$972k
NEI NIH HHS R01 EY011309NEI NIH HHS R01 EY022445NEI NIH HHS R01 EY028602
6 · The paper itself

Abstract

backgroundTransitions between different stages of age-related macular degeneration (AMD) are not completely captured by traditional survival models with an end point of advanced AMD.

objectivesThis study aimed to explore the transitions from early and intermediate AMD to higher non-advanced and advanced stages and determine the contributions of nutritional factors to these outcomes.

methodsEyes with early or intermediate AMD at baseline, classified according to the Age-Related Eye Disease Study severity scale, were included in this prospective longitudinal analysis. Foods and the biologically active nutrients associated with AMD [green leafy vegetables, fish, lutein/zeaxanthin (LZ), and ω-3 (n-3) fatty acids] were determined by a baseline food frequency questionnaire. Progression was defined as eyes transitioning to higher severity groups including non-advanced and advanced stages over 5 years, confirmed at 2 consecutive visits. Cox proportional hazards models for foods and nutrients were analyzed adjusting for demographics, lifestyle, baseline macular status, a family history of AMD, caloric intake, and genetic risk.

resultsAmong 2697 eyes, 616 (23%) progressed to higher severity groups. In the food group model, higher intake of green leafy vegetables reduced incidence of transitions {hazard ratio [HR] (≥2.7 servings/wk compared with none): 0.75; 95% confidence interval [CI]: 0.59, 0.96; P = 0.02}. Higher fish intake was also protective [HR (≥ two 4-ounce servings/wk compared with <2): 0.79; 95% CI: 0.65, 0.95; P = 0.01]. In the nutrient model, LZ intake was protective [HR (≥2 mg/d compared with <2): 0.76; 95% CI: 0.60, 0.96; P = 0.02]. Higher intake of ω-3 fatty acids also tended to be beneficial [HR (≥0.7 g/wk compared with <0.7): 0.85; 95% CI: 0.71, 1.01; P = 0.06].

conclusionsIncreased consumption of green leafy vegetables, LZ, and fish nutritionally rich in ω-3 fatty acids during the initial stages of AMD may reduce rates of progression to higher severity of this debilitating disease. This trial was registered at clinicaltrials.gov as NCT00594672.

Indexed as

Macular DegenerationAgedAged, 80 and overDietDisease ProgressionFatty Acids, Omega-3FemaleHumansLongitudinal StudiesLuteinMaleMiddle AgedNutritional StatusProspective StudiesVegetablesFatty Acids, Omega-3Luteinage-related macular degenerationfishgreen leafy vegetablesincreasing severity of AMDlutein/zeaxanthinseverity groupstransitions to higher non-advanced and advanced stages of age-related macular degenerationω-3 fatty acids

Identifiers

PMID39181206
PMCPMC11619796

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.