Evidence map›Paper›PMID 39181385›Full record

ArticleBiological psychiatry2025

Corticotropin-Releasing Factor Release From a Unique Subpopulation of Accumbal Neurons Constrains Action-Outcome Acquisition in Reward Learning.

Elizabeth A Eckenwiler, Anna E Ingebretson, Jeffrey J Stolley, Maxine A Fusaro, Alyssa M Romportl, Jack M Ross, Christopher L Petersen, Eera M Kale, Michael S Clark, Selena S Schattauer and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Elizabeth A EckenwilerDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Anna E IngebretsonDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Jeffrey J StolleyDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Maxine A FusaroDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Alyssa M RomportlDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Jack M RossDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Christopher L PetersenDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Eera M KaleDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota.
Michael S ClarkDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Selena S SchattauerDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington; Department of Pharmacology, University of Washington, Seattle, Washington.
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington; Department of Pharmacology, University of Washington, Seattle, Washington.
Julia C LemosDepartment of Neuroscience, University of Minnesota Twin Cities, Minneapolis, Minnesota; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota. Electronic address: jlemos@umn.edu.

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2019 to 2026
$13.0M
Determining the unique and dynamic neural constellation belonging to acute and chronic stress statesR01MH122749 · NIMH · UNIVERSITY OF MINNESOTA · PI LEMOS, JULIA C · 2020 to 2024
$2.4M
CRF actions in the nucleus accumbens in mice with different life historiesR00MH109627 · NIMH · UNIVERSITY OF MINNESOTA · PI LEMOS, JULIA C · 2018 to 2020
$747k
Investigation of a novel ventral pallidum population expressing corticotropin-releasing factor receptor 1F31DA059436 · NIDA · UNIVERSITY OF MINNESOTA · PI ECKENWILER, ELIZABETH ANNE · 2023 to 2024
$71k
NIDA NIH HHS F31 DA059436NIDA NIH HHS P30 DA048736NIDA NIH HHS P30 DA048742NIMH NIH HHS K99 MH109627NIMH NIH HHS R00 MH109627NIMH NIH HHS R01 MH122749
6 · The paper itself

Abstract

backgroundThe nucleus accumbens (NAc) mediates reward learning and motivation. Despite an abundance of neuropeptides, peptidergic neurotransmission from the NAc has not been integrated into current models of reward learning. The existence of a sparse population of neurons containing corticotropin-releasing factor (CRF) has been previously documented. Here, we provide a comprehensive analysis of their identity and functional role in shaping reward learning.

methodsOur multidisciplinary approach included fluorescent in situ hybridization (n = ≥3 mice), tract tracing (n = 5 mice), ex vivo electrophysiology (n = ≥30 cells), in vivo calcium imaging with fiber photometry (n = ≥4 mice), and use of viral strategies in transgenic lines to selectively delete CRF peptide from NAc neurons (n = ≥4 mice). Behaviors used were instrumental learning, sucrose preference, and spontaneous exploration in an open field.

resultsWe showed that the vast majority of NAc CRF-containing neurons are spiny projection neurons (SPNs) comprising dopamine D

conclusionsCRF release from this sparse population of SPNs is critical for reward learning under normal conditions.

Indexed as

Corticotropin-Releasing HormoneLearningNeuronsNucleus AccumbensRewardAnimalsConditioning, OperantMaleMiceMice, Inbred C57BLMice, TransgenicCorticotropin-Releasing HormoneCorticotropin-releasing factorElectrophysiologyMesolimbic systemNeuropeptidesNoveltyNucleus accumbensReward learningSpiny projection neuronStressStriatum

Identifiers

PMID39181385
PMCPMC11839403

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.