Evidence map›Paper›PMID 39185522›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Alzheimer's disease protective allele of

Xiaojie Zhao, Yan Li, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Alena Kozlova, Matthew J Moulton, Lindsey D Goodman, Zhiping P Pang, Alan R Sanders and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Xiaojie ZhaoCenter for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Yan LiDepartment of Bioinformatic, Nanjing Medical University, Nanjing, Jiangsu, 211166, China.
Siwei ZhangCenter for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.ORCID 0000-0002-1646-063X
Ari SudwartsByrd Alzheimer's Center and Research Institute, University of South Florida, Tampa, FL 33613, USA.
Hanwen ZhangCenter for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Alena KozlovaCenter for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Matthew J MoultonJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Lindsey D GoodmanJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Zhiping P PangDepartment of Neuroscience and Cell Biology, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.ORCID 0000-0002-6183-1233
Alan R SandersCenter for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Hugo J BellenJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Gopal ThinakaranByrd Alzheimer's Center and Research Institute, University of South Florida, Tampa, FL 33613, USA.
Jubao DuanCenter for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.

Funding

Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila ModelsU01AG072439 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J, BOTAS, JUAN · 2021 to 2025
$8.4M
Systematic Functional Interpretation of Regulatory Variants in SchizophreniaR01MH106575 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO · 2016 to 2025
$6.1M
Modeling Alzheimer's disease genetic variants in hiPSCR01AG063175 · NIA · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DUAN, JUBAO, THINAKARAN, GOPAL · 2019 to 2023
$3.7M
Integrating epigenomics with DNA breathing dynamics for human non-coding disease variantsR01MH116281 · NIMH · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI ALEXANDROV, BOIAN STOIANOV, DUAN, JUBAO · 2019 to 2023
$3.0M
Neuronal Vulnerability to Lipid Droplets and Cholesterol in Alzheimer's DiseaseR01AG081374 · NIA · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI Jubao Duan · 2023 to 2026
$2.7M
IMPACTS OF GLIAL LIPID DROPLETS ON OXIDATIVE STRESS AND NEURODEGENERATION IN ALZHEIMER'S DISEASER01AG073260 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2021 to 2025
$2.6M
Microglial function of GWAS risk factor BIN1 in Alzheimer's disease pathogenesis and inflammatory signalingRF1AG079141 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI RANGARAJU, SRIKANT, THINAKARAN, GOPAL · 2022 to 2022
$2.3M
NIA NIH HHS R01 AG063175NIA NIH HHS R01 AG073260NIA NIH HHS R01 AG081374NIA NIH HHS RF1 AG079141NIA NIH HHS U01 AG072439NIMH NIH HHS R01 MH106575NIMH NIH HHS R01 MH116281
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms remain largely unknown. For a strong AD-associated locus near

Indexed as

allele-specific open chromatinAlzheimer’s diseaseClusteringenome-wide association studyiPSClipid dropletsneuron excitabilityneuron-glia lipid transferprotective allele

Identifiers

PMID39185522
PMCPMC11343251

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.