Evidence map›Paper›PMID 39185682›Full record

ArticleGut microbes

Gut virome and microbiome dynamics before and after SARS-CoV-2 infection in women living with HIV and their infants.

Rabia Maqsood, LaRinda A Holland, Lily I Wu, Emily R Begnel, Judith Adhiambo, Prestone Owiti, Bhavna H Chohan, Soren Gantt, John Kinuthia, Dalton Wamalwa and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Rabia MaqsoodCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
LaRinda A HollandCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Lily I WuCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Emily R BegnelDepartment of Global Health, University of Washington, Seattle, WA, USA.
Judith AdhiamboDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Prestone OwitiDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Bhavna H ChohanDepartment of Global Health, University of Washington, Seattle, WA, USA.
Soren GanttDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Centre de Recherche du CHU St-Justine, Montreal, Québec, Canada.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, WA, USA.
Dalton WamalwaDepartment of Global Health, University of Washington, Seattle, WA, USA.
Ednah OjeeDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Barbra A RichardsonDepartment of Global Health, University of Washington, Seattle, WA, USA.
Jennifer SlykerDepartment of Global Health, University of Washington, Seattle, WA, USA.
Dara A LehmanDepartment of Global Health, University of Washington, Seattle, WA, USA.
Efrem S LimCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-3397-9310

Funding

The effect of cytomegalovirus, inflammation, and immune activation on neurodevelopment in children exposed to maternal HIV infectionP01HD107669 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, John Kinuthia · 2022 to 2026
$8.8M
Maternal-infant Virome Transmission: the role of HIV and Antiretroviral TherapyR01HD092311 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEHMAN, DARA ANN · 2017 to 2021
$3.9M
NICHD NIH HHS P01 HD107669NICHD NIH HHS R01 HD092311
6 · The paper itself

Abstract

Microbiome perturbations can have long-term effects on health. The dynamics of the gut microbiome and virome in women living with HIV (WLHIV) and their newborn infants is poorly understood. Here, we performed metagenomic sequencing analyses on longitudinal stool samples including 23 mothers (13 WLHIV, 10 HIV-negative) and 12 infants that experienced SARS-CoV-2 infection with mild disease, as well as 40 mothers (18 WLHIV, 22 HIV-negative) and 60 infants that remained SARS-CoV-2 seronegative throughout the study follow-up. Regardless of HIV or SARS-CoV-2 status, maternal bacterial and viral profiles were distinct from infants. Using linear mixed effects models, we showed that the microbiome alpha diversity trajectory was not significantly different between SARS-CoV-2 seropositive and seronegative women. However, seropositive women's positive trajectory while uninfected was abruptly reversed after SARS-CoV-2 infection (

Indexed as

COVID-19FecesGastrointestinal MicrobiomeHIV InfectionsSARS-CoV-2ViromeAdultBacteriaFemaleHumansInfantInfant, NewbornLongitudinal Studiesbacterial microbiomegutHIVlongitudinalmothers and infantsSARS-CoV-2virome

Identifiers

PMID39185682
PMCPMC11352790

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.