Evidence map›Paper›PMID 39186134›Full record

ReviewSeminars in immunopathology2024

The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits.

Ole Bæk, Frederik Schaltz-Buchholzer, Anita Campbell, Nelly Amenyogbe, James Campbell, Peter Aaby, Christine Stabell Benn, Tobias R Kollmann

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Route of BCG administration determines success.Human vaccines & immunotherapeutics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ole Bæk *University of Copenhagen, Copenhagen, Denmark.
Frederik Schaltz-Buchholzer *University of Southern Denmark, Copenhagen, Denmark.
Anita Campbell *Telethon Kids Institute, Perth, Australia.
Nelly AmenyogbeTelethon Kids Institute, Perth, Australia.
James CampbellCentral Perth Skin Clinic, Perth, Australia.
Peter AabyBandim Health Project, Bissau, Guinea-Bissau.
Christine Stabell BennUniversity of Southern Denmark, Copenhagen, Denmark.
Tobias R KollmannTelethon Kids Institute, Perth, Australia. tkollm@mac.com.ORCID 0000-0003-2403-9762

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin scar formation following Bacille Calmette-Guérin (BCG) or smallpox (Vaccinia) vaccination is an established marker of successful vaccination and 'vaccine take'. Potent pathogen-specific (tuberculosis; smallpox) and pathogen-agnostic (protection from diseases unrelated to the intentionally targeted pathogen) effects of BCG and smallpox vaccines hold significant translational potential. Yet despite their use for centuries, how scar formation occurs and how local skin-based events relate to systemic effects that allow these two vaccines to deliver powerful health promoting effects has not yet been determined. We review here what is known about the events occurring in the skin and place this knowledge in the context of the overall impact of these two vaccines on human health with a particular focus on maternal-child health.

Indexed as

BCG VaccineCicatrixSkinSmallpox VaccineVaccinationAnimalsHumansSmallpoxBCG VaccineSmallpox VaccineBCGDermoscopyMaternal child healthSmallpoxSpatial genomicsVaccine scar

Identifiers

PMID39186134
PMCPMC11347488

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.