Evidence map›Paper›PMID 39187387›Full record

ReviewMolecular pharmacology2024

Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated G

Morgan B Dwyer, Jenna L Aumiller, Philip B Wedegaertner

Abstract readReview
In one paragraph

Review in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Morgan B DwyerDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Jenna L AumillerDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Philip B WedegaertnerDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania philip.wedegaertner@jefferson.edu.

Funding

Training Grant in Cellular, Biochemical and Molecular SciencesT32GM144302 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI DIANE E MERRY, PHILIP B WEDEGAERTNER · 2022 to 2026
$2.0M
Regulation of Mutationally Activated Gq/11R01GM138943 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WEDEGAERTNER, PHILIP B · 2021 to 2024
$1.2M
NIGMS NIH HHS R01 GM138943NIGMS NIH HHS T32 GM144302
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) couple to heterotrimeric G proteins, comprised of

Indexed as

MutationNeoplasmsAnimalsGTP-Binding Protein alpha SubunitsHumansReceptors, G-Protein-CoupledSignal TransductionGTP-Binding Protein alpha SubunitsReceptors, G-Protein-Coupled

Identifiers

PMID39187387
PMCPMC11493338

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.