Evidence map›Paper›PMID 39188304›Full record

ArticleMolecular therapy. Nucleic acids2024

The roles of CD4

Samita Kafle, Brian Montoya, Lingjuan Tang, Ying K Tam, Hiromi Muramatsu, Norbert Pardi, Luis J Sigal

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Distinct Requirements for CD4European journal of immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samita KafleDepartment of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Brian MontoyaDepartment of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lingjuan TangDepartment of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Ying K TamAcuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
Hiromi MuramatsuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Norbert PardiDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Luis J SigalDepartment of Microbiology and Immunology, Bluemle Life Science Building, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Funding

Project 4: Computational panbetaCoV immunogen designP01AI158571 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2021 to 2023
$28.0M
Mapping spatiotemporal dynamics during enterovirus infection across cells and tissuesR01AI169460 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raul Andino, Luis J Sigal · 2022 to 2026
$4.5M
Lipid nanoparticles as novel adjuvants inducing effective T follicular helper cell and humoral immune responsesR01AI153064 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michela Locci, Norbert Pardi · 2020 to 2026
$4.2M
Development of Universal Influenza Virus Vaccines Using Nucleoside-Modified Messenger RNAR01AI146101 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PARDI, NORBERT · 2019 to 2023
$3.1M
Mechanisms of protective memory CD8 T-cell induction by mRNA-LNP vaccinesR01AI175567 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI Luis J Sigal · 2023 to 2026
$2.8M
Training grant on Vaccines and Immunotherapies for Infectious Diseases and CancerT32AI134646 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SCHNELL, MATTHIAS JOHANNES, SIGAL, LUIS J · 2018 to 2022
$1.1M
The Immune Response to Ectromelia Virus in the Draining Lymph NodeR56AI110457 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SIGAL, LUIS J · 2014 to 2021
$1.0M
NIAID NIH HHS P01 AI158571NIAID NIH HHS R01 AI146101NIAID NIH HHS R01 AI153064NIAID NIH HHS R01 AI169460NIAID NIH HHS R01 AI175567NIAID NIH HHS R56 AI110457NIAID NIH HHS T32 AI134646
6 · The paper itself

Abstract

The role of CD4

Indexed as

CD4+ T cell helpCD8+ T cellsectromelia virusfemalemalemousemousepoxmRNA-LNPMT: Oligonucleotides: Therapies and Applicationspoxvirusvaccines

Identifiers

PMID39188304
PMCPMC11345529

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.