ArticlePlant biotechnology journal2025
AaMYC3 bridges the regulation of glandular trichome density and artemisinin biosynthesis in Artemisia annua.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Alternative Artemisinin Production Strategies.International journal of molecular sciences · 2025Pooled it
- From Model Plants toPlants (Basel, Switzerland) · 2026Review
- Heterologous expression of DobHLH25 from Dendrobium officinale enhances drought tolerance in Arabidopsis.Functional & integrative genomics · 2026Article
- Review
- Genome-Wide Identification and Expression Analysis of the NIN-LIKE Protein (NLP) Gene Family in Salvia Miltiorrhiza.Biochemical genetics · 2026Article
- Review
- Regulatory architecture of high-altitude adaptation in Artemisia: from signal perception to specialized metabolism.Plant cell reports · 2026Review
- Insights into glandular trichome biology from analysis of organ-specific gene expression programmes in cannabis, hop and tomato.The Plant journal : for cell and molecular biology · 2026Article
- Differential effects of biologically and chemically synthesized copper oxide nanoparticles on artemisinin biosynthesis gene expression in Artemisia absinthium.Scientific reports · 2026Article
- The Genetic Wiring of Plant Trichomes: From Initiation to Fate Specification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- KoreanFrontiers in pharmacology · 2026Review
- Safeguarding artemisinin: integrating bioproduction innovation and resistance management for malaria eradication.Malaria journal · 2025Review
- Transcriptome-wide analysis of AlbHLH gene family in Atractylodes lancea (Thunb.) DC and functional exploration of AlbHLH3 in regulating terpenoid biosynthesis.BMC plant biology · 2025Article
- Graphene oxide enhances aphid resistance in sorghum via the miR319-SbTCP7-SbLOX3 Pathway.Plant biotechnology journal · 2025Article
- The Role of MYC2 Transcription Factors in Plant Secondary Metabolism and Stress Response Mechanisms.Plants (Basel, Switzerland) · 2025Review
- Seed priming with graphene oxide improves salinity tolerance and increases productivity of peanut through modulating multiple physiological processes.Journal of nanobiotechnology · 2024Article
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7 authors.
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Abstract
Artemisinin, the well-known natural product for treating malaria, is biosynthesised and stored in the glandular-secreting trichomes (GSTs) of Artemisia annua. While numerous efforts have clarified artemisinin metabolism and regulation, the molecular association between artemisinin biosynthesis and GST development remains elusive. Here, we identified AaMYC3, a bHLH transcription factor of A. annua, induced by jasmonic acid (JA), which simultaneously regulates GST density and artemisinin biosynthesis. Overexpressing AaMYC3 led to a substantial increase in GST density and artemisinin accumulation. Conversely, in the RNAi-AaMYC3 lines, both GST density and artemisinin content were markedly reduced. Through RNA-seq and analyses conducted both in vivo and in vitro, AaMYC3 not only directly activates AaHD1 transcription, initiating GST development, but also up-regulates the expression of artemisinin biosynthetic genes, including CYP71AV1 and ALDH1, thereby promoting artemisinin production. Furthermore, AaMYC3 acts as a co-activator, interacting with AabHLH1 and AabHLH113, to trigger the transcription of two crucial enzymes in the artemisinin biosynthesis pathway, ADS and DBR2, ultimately boosting yield. Our findings highlight a critical connection between GST initiation and artemisinin biosynthesis in A. annua, providing a new target for molecular design breeding of traditional Chinese medicine.
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