Evidence map›Paper›PMID 39189154›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2024

Alzheimer's Disease-Related Analytes Amyloid-β and Tau in Perilymph: Correlation With Patient Age and Cognitive Score.

Amit Walia, Matthew A Shew, Nedim Durakovic, Jacques A Herzog, John R Cirrito, Carla M Yuede, Cameron C Wick, Melissa Manis, David M Holtzman, Craig A Buchman and 1 more

Abstract read
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amit WaliaDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.ORCID http://orcid.org/0000-0002-1061-0561
Matthew A ShewDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Nedim DurakovicDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Jacques A HerzogDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
John R CirritoDepartment of Neurology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Carla M YuedeDepartment of Neurology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Cameron C WickDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Melissa ManisDepartment of Neurology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
David M HoltzmanDepartment of Neurology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Craig A BuchmanDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
Mark A RutherfordDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.

Funding

EXCITATION AND EXCITOTOXICITY IN TYPE I COCHLEAR AFFERENTS: SYNAPTIC STRUCTURE AND FUNCTIONR01DC014712 · NIDCD · WASHINGTON UNIVERSITY · PI Mark Allen Rutherford · 2016 to 2026
$5.6M
DEVELOPMENT OF CLINICIAN/RESEARCHERS IN ACADEMIC ENTT32DC000022 · NIDCD · WASHINGTON UNIVERSITY · PI PICCIRILLO, JAY F. · 1989 to 2022
$5.6M
Predicting Performance in Adult Cochlear ImplantationR01DC020936 · NIDCD · WASHINGTON UNIVERSITY · PI Craig A. Buchman · 2023 to 2026
$2.5M
NIDCD NIH HHS R01 DC014712NIDCD NIH HHS R01 DC020936NIDCD NIH HHS T32 DC000022
6 · The paper itself

Abstract

objectiveTo describe the collection methods for perilymph fluid biopsy during cochlear implantation, detect levels of amyloid β 42 and 40 (Aβ STUDY

designProspective study.

settingTertiary referral center.

methodsPerilymph was collected from 25 patients using polyimide tubing to avoid amyloid adherence to glass, and analyzed with a single-molecule array advanced digital enzyme-linked immunosorbent assay platform for Aβ

resultsPerilymph volumes ranged from ∼1 to 13 µL, with analyte concentrations spanning 2.67 to 1088.26 pg/mL. All samples had detectable levels of tTau, Aβ

conclusionAlzheimer's disease-associated peptides Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPerilymphtau ProteinsAdultAgedAged, 80 and overAge FactorsBiomarkersCochlear ImplantationCognitionEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMental Status and Dementia TestsAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer's diseaseamyloidAβ40Aβ42cochlear implantationcognitionMoCAperilymphtau

Identifiers

PMID39189154
PMCPMC11606756

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.