Evidence map›Paper›PMID 39189257›Full record

ArticleEpigenomes2024

Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration.

Gillian England-Mason, Sarah M Merrill, Jiaying Liu, Jonathan W Martin, Amy M MacDonald, David W Kinniburgh, Nicole Gladish, Julia L MacIsaac, Gerald F Giesbrecht, Nicole Letourneau and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gillian England-MasonDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0003-0633-5963
Sarah M MerrillDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School at Brown University, Providence, RI 02903, USA.
Jiaying LiuDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Jonathan W MartinScience for Life Laboratory, Department of Environmental Science, Stockholm University, 114 19 Stockholm, Sweden.ORCID 0000-0001-6265-4294
Amy M MacDonaldAlberta Centre for Toxicology, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0001-7031-8952
David W KinniburghDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Nicole GladishDepartment of Medical Genetics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Julia L MacIsaacDepartment of Medical Genetics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Gerald F GiesbrechtDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
Nicole LetourneauDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0002-7468-915X
Michael S KoborDepartment of Medical Genetics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Deborah DeweyDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0002-1323-5832

Funding

Alberta Pregnancy Outcomes and Nutrition (APrON) - Toxicant-Diet Interactions onR21ES021295 · NIEHS · UNIVERSITY OF ALBERTA · PI MARTIN, JONATHAN WAYNE · 2012 to 2014
$320k
CIHR MOP-123535CIHR PG-425614NIEHS NIH HHS R21 ES021295NIH HHS 1R21ES021295-01R21
6 · The paper itself

Abstract

We examined whether prenatal exposure to two classes of endocrine-disrupting chemicals (EDCs) was associated with infant epigenetic age acceleration (EAA), a DNA methylation biomarker of aging. Participants included 224 maternal-infant pairs from a Canadian pregnancy cohort study. Two bisphenols and 12 phthalate metabolites were measured in maternal second trimester urines. Buccal epithelial cell cheek swabs were collected from 3 month old infants and DNA methylation was profiled using the Infinium MethylationEPIC BeadChip. The Pediatric-Buccal-Epigenetic tool was used to estimate EAA. Sex-stratified robust regressions examined individual chemical associations with EAA, and Bayesian kernel machine regression (BKMR) examined chemical mixture effects. Adjusted robust models showed that in female infants, prenatal exposure to total bisphenol A (BPA) was positively associated with EAA (

Indexed as

APrONbisphenol Adevelopmental origins of health and diseaseDNA methylationepigenetic clockphthalates

Identifiers

PMID39189257
PMCPMC11348373

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.