Evidence map›Paper›PMID 39189609›Full record

SynthesisCardiovascular research2024

Burden of risk factors in women and men with unrecognized myocardial infarction: a systematic review and meta-analysis †.

Julie A E van Oortmerssen, Noluthando Ntlapo, Martijn J Tilly, Wichor M Bramer, Hester M den Ruijter, Eric Boersma, Maryam Kavousi, Jeanine E Roeters van Lennep

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julie A E van OortmerssenDepartment of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.ORCID 0009-0005-3156-4508
Noluthando NtlapoDepartment of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8125-7446
Martijn J TillyDepartment of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-0990-3316
Wichor M BramerMedical Library, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0003-2681-9180
Hester M den RuijterLaboratory for Experimental Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-9762-014X
Eric BoersmaDepartment of Cardiology, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-2559-7128
Maryam KavousiDepartment of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-5976-6519
Jeanine E Roeters van LennepDepartment of Internal Medicine, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-6870-9962

Funding

Dutch Heart Foundation 2020B004
6 · The paper itself

Abstract

Unrecognized myocardial infarction (MI) is an MI that remains undetected in the acute phase and is associated with an unfavourable prognosis. With this systematic review and meta-analysis, we evaluated the burden of cardiovascular risk factors in individuals with unrecognized MI. We searched general population-based cohort studies diagnosing unrecognized MI by electrocardiogram or myocardial imaging up to 24 November 2023. Pooled mean differences (MDs) or risk ratios (RRs) with 95% confidence intervals (CIs) were determined, and random-effects meta-analyses were performed. Fourteen cohort studies were included involving 200 450 individuals (mean age 62.8 ± 9.9 years, 56.0% women), among which 4322 (2.2%) experienced unrecognized MI (mean age 66.3 ± 8.2 years, 47.8% women) and 4653 (2.1%) recognized MI (mean age 68.5 ± 7.3 years, 33.8% women). Compared to individuals without MI, those with unrecognized MI had higher body mass index (MD 0.27, 95% CI 0.16-0.39) and systolic blood pressure (MD 4.48, 95% CI 2.81-6.15) levels, and higher prevalence of hypertension (RR 1.27, 95% CI 1.06-1.51) and diabetes mellitus (RR 1.67, 95% CI 1.36-2.06). Furthermore, individuals with unrecognized MI had lower prevalence of hypertension (RR 0.92, 95% CI 0.88-0.97) and diabetes mellitus (RR 0.80, 95% CI 0.70-0.92). Individuals with unrecognized MI are characterized by a substantial burden of metabolic risk factors. Our findings suggest insufficient recognition and management of cardiovascular risk factors among individuals with unrecognized MI.

Indexed as

Heart Disease Risk FactorsMyocardial InfarctionAgedFemaleHumansHypertensionMaleMiddle AgedPrevalencePrognosisRisk AssessmentRisk FactorsSex FactorsAsymptomatic diseaseGeneral populationHeart disease risk factorsSilent myocardial infarctionUnrecognized myocardial infarction

Identifiers

PMID39189609
PMCPMC11587555

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.