Evidence map›Paper›PMID 39190580›Full record

Trial reportExperimental physiology2024

Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions.

Tyler S McClure, Jeffrey Phillips, Andrew P Koutnik, Kody Coleman, Ed Chappe, Gary R Cutter, Brendan Egan, Todd Norell, Brianna J Stubbs, Marcas M Bamman and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Ketone monoester ingestion and cognitive and physical performance during exercise-heat stress.Journal of the International Society of Sports Nutrition · 2026
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  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tyler S McClureSchool of Health and Human Performance, Dublin City University, Dublin, Ireland.
Jeffrey PhillipsHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.
Andrew P KoutnikHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.ORCID https://orcid.org/0000-0002-5491-3919
Kody ColemanHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.
Ed ChappeHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.
Gary R CutterHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.
Brendan EganSchool of Health and Human Performance, Dublin City University, Dublin, Ireland.ORCID https://orcid.org/0000-0001-8327-9016
Todd NorellHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.
Brianna J StubbsBuck Institute for Research on Aging, Novato, California, USA.
Marcas M BammanHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.
Dawn KernagisHealthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition, Pensacola, Florida, USA.ORCID https://orcid.org/0009-0009-2058-8730

Funding

Office of Naval Research Global 19-8-004United States Special Operations Command H9240519C0016
6 · The paper itself

Abstract

Exogenous ketone supplements are a potential augmentation strategy for cognitive resilience during acute hypoxic exposure due to their capacity to attenuate the decline in oxygen (O

Indexed as

CognitionCross-Over StudiesHypoxia3-Hydroxybutyric AcidAdultBlood GlucoseHumansKetonesMaleMilitary PersonnelOxygenOxygen SaturationRestSingle-Blind MethodYoung Adult3-Hydroxybutyric AcidBlood GlucoseKetonesOxygencode substitutioncognitive resilienceexogenous ketosisβ‐hydroxybutyrate

Identifiers

PMID39190580
PMCPMC11442756

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.