Evidence map›Paper›PMID 39190707›Full record

ArticleScience signaling2024

Chemokine-mediated F-actin dynamics, polarity, and migration in B lymphocytes depend on WNK1 signaling.

Il-Young Hwang, Ji Sung Kim, Kathleen A Harrison, Chung Park, Chong Shan Shi, John H Kehrl

Abstract read
In one paragraph

Article in Science signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. ΔJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Il-Young HwangB-cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-4498-4382
Ji Sung KimB-cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0003-8943-5771
Kathleen A HarrisonB-cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chung ParkB-cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7819-5333
Chong Shan ShiB-cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
John H KehrlB-cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6526-159X

Funding

CONTROL OF G PROTEIN SIGNALING: ROLE OF THE RGSSZ01AI000738 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI KEHRL, JOHN H · 1996 to 2008
$3.9M
SIGNAL TRANSDUCTION IN B LYMPHOCYTES: INDENTIFICATION OF KEY SIGNALING MOLECULEZ01AI000739 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI KEHRL, JOHN H · 1996 to 2008
$1.5M
Intramural NIH HHS Z01 AI000738Intramural NIH HHS Z01 AI000739
6 · The paper itself

Abstract

Ligand-engaged chemokine receptors trigger nucleotide exchange in heterotrimeric Gα

Indexed as

ActinsB-LymphocytesCell PolaritySignal TransductionWNK Lysine-Deficient Protein Kinase 1AnimalsCell MovementChemokine CXCL13GTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsMiceMice, Inbred C57BLProto-Oncogene Proteins c-aktReceptors, CXCR5ActinsChemokine CXCL13CXCR5 protein, mouseDOCK2 protein, mouseGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsProto-Oncogene Proteins c-aktReceptors, CXCR5Wnk1 protein, mouseWNK Lysine-Deficient Protein Kinase 1

Identifiers

PMID39190707
PMCPMC11542683

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.