Evidence map›Paper›PMID 39191800›Full record

ArticleScientific reports2024

Deficiency of interleukin-1 receptor antagonist in mice differentially affects bone properties under different genomic backgrounds.

Wei Dong, Cheng Tian, Z Galvin Li, Matthew Bounds, Jiamin Ma, David D Brand, Xiaoyun Liu, Yanhong Cao, Arielle Beard, Jian Yan and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wei DongDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Cheng TianSaint Jude Children's Research Hospital, Memphis, TN, USA.
Z Galvin LiDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Matthew BoundsDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Jiamin MaDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
David D BrandLt. Col. Luke Weathers, Jr. VA Medical Center, 116 N Pauline St., Memphis, TN, 38105, USA.
Xiaoyun LiuCenter for Clinical Precision Medication, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China.
Yanhong CaoInstitute of Kaschin-Beck Disease, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key Laboratory of Etiologic Epidemiology, Education Bureau of Heilongjiang Province and Ministry of Health (23618104), Harbin Medical University, Harbin, 150081, People's Republic of China.
Arielle BeardDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Jian YanDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Karen HastyDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
John StuartDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Kui LiDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Hongsik ChoDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Elizabeth A FitzpatrickDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Linda K MyersDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Yan JiaoDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. yjiao2@utshc.edu.
Weikuan GuDepartment of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. wgu@uthsc.edu.

Funding

MUTATION SCREENING OF SKELETAL DISEASE MOUSE MODELSR01AR051190 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GU, WEIKUAN · 2004 to 2007
$1.1M
Pathogenic pathways involved in spontaneous arthritisR01AR050785 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI STUART, JOHN M · 2003 to 2006
$942k
Study of the Genetic Basis for Fibrotic Diseases in a Mouse ModelI01BX000671 · VA · MEMPHIS VA MEDICAL CENTER · PI GU, WEIKUAN · 2012 to 2015
–
An Innovative Two-Step Therapeutic Strategy to Maximize the Effect of Stem Cell Therapy for Post-Traumatic OsteoarthritisI01RX004283 · VA · MEMPHIS VA MEDICAL CENTER · PI Hongsik Jake Cho · 2023 to 2026
–
BLRD VA I01 BX000671NIAMS NIH HHS R01 AR050785NIAMS NIH HHS R01 AR051190NIH HHS R01 AR50785NIH HHS R01 AR51190RRD VA I01 RX004283U.S. Department of Veterans Affairs 1I01RX004283
6 · The paper itself

Abstract

When IL-1 receptor antagonist (IL-1rn) is knocked out, mice have shown strain background dependent and major QTL regulated susceptibility to spontaneously inflammatory arthritis disease (SAD). The impact on bone properties resulting from the interactions of IL-1rn, genomic background strains, and the QTL locus, is unknown. Bone properties in the four specifically bred mouse strains with mutation of IL-1rn and variations in genomic components were investigated with high-resolution MicroCT and genomic analytical tools. Two congenic mouse strains were also measured to evaluate the influence on bone properties by a QTL in the region in chromosome 1. Our results reveal that several bone phenotypes, including bone mineral density (BMD), bone volume, tibial length, and cortical thickness of the tibia are different between wild type and IL-1rn knockout mice in both Balb/c and DBA/1 backgrounds, but IL-1rn knockout affects BMD differently between the two mouse strains. The absence of IL-1rn decreases BMD in Balb/c mice but increases BMD in DBA/1

Indexed as

Bone DensityInterleukin 1 Receptor Antagonist ProteinMice, KnockoutQuantitative Trait LociAnimalsBone and BonesHereditary Autoinflammatory DiseasesMaleMiceMice, Inbred BALB CMice, Inbred DBAPhenotypeX-Ray MicrotomographyIl1rn protein, mouseInterleukin 1 Receptor Antagonist ProteinArthritisBMDIfi202bIL1rnQTL

Identifiers

PMID39191800
PMCPMC11349940

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.