Evidence map›Paper›PMID 39191809›Full record

Trial reportScientific reports2024

Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial.

Vinicius Tadeu Ramos da Silva Grillo, Matheus Bertanha, Lenize da Silva Rodrigues, Marcelo Andrade de Lima, Pedro Luciano Mellucci Filho, Rafael Rahal Guaragna Machado, Edson Luiz Durigon, Nathália Dias Sertorio, Marjorie de Assis Golim, Andrei Moroz and 16 more

Abstract readRandomized Controlled TrialClinical Trial, Phase IIClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Vinicius Tadeu Ramos da Silva GrilloDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University - UNESP, Clinical Hospital, Professor Montenegro Avenue, Botucatu, SP, 18618687, Brazil.
Matheus BertanhaDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University - UNESP, Clinical Hospital, Professor Montenegro Avenue, Botucatu, SP, 18618687, Brazil. matheusbertanha@gmail.com.
Lenize da Silva RodriguesDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University - UNESP, Clinical Hospital, Professor Montenegro Avenue, Botucatu, SP, 18618687, Brazil.
Marcelo Andrade de LimaCentre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire, UK.
Pedro Luciano Mellucci FilhoDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University - UNESP, Clinical Hospital, Professor Montenegro Avenue, Botucatu, SP, 18618687, Brazil.
Rafael Rahal Guaragna MachadoDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, - USP, São Paulo, Brazil.
Edson Luiz DurigonDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, - USP, São Paulo, Brazil.
Nathália Dias SertorioDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University - UNESP, Clinical Hospital, Professor Montenegro Avenue, Botucatu, SP, 18618687, Brazil.
Marjorie de Assis GolimApplied Biotechnology Laboratory, Research Nucleus of Clinical Hospital, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Andrei MorozDepartment of Bioprocess and Biotechnology, School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, SP, Brazil.
Aline Márcia Marques BrazApplied Biotechnology Laboratory, Research Nucleus of Clinical Hospital, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Leonardo Nazário de MoraesApplied Biotechnology Laboratory, Research Nucleus of Clinical Hospital, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Marco Antonio LeiteClinical Hospital of the Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Helena Bonciani NaderDepartment of Biochemistry, Federal University of São Paulo - UNIFESP, São Paulo, SP, Brazil.
Gustavo Constantino de CamposDepartment of Orthopedics and Traumatology, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, SP, Brazil.
Cristiane Rodrigues Guzzo CarvalhoDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, - USP, São Paulo, Brazil.
Fábio Florença CardosoDepartment of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Angelo José MagroDepartment of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Helga Caputo NunesTeaching and Research Center of the Albert Einstein Hospital, São Paulo, SP, Brazil.
Rejane Maria Tommasini GrottoApplied Biotechnology Laboratory, Research Nucleus of Clinical Hospital, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Rita de Cássia AlvaradoApplied Biotechnology Laboratory, Research Nucleus of Clinical Hospital, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Maria Inês de Moura Campos PardiniInternal Medicine Division, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Marcone Lima SobreiraDepartment of Surgery and Orthopedics, Botucatu Medical School, São Paulo State University - UNESP, Clinical Hospital, Professor Montenegro Avenue, Botucatu, SP, 18618687, Brazil.
Erika Alessandra Pellison Nunes da CostaDepartment of Infectious Diseases, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Alexandre Naime BarbosaDepartment of Infectious Diseases, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
Carlos Magno Castelo Branco FortalezaDepartment of Infectious Diseases, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.

Funding

Academy of Medical Sciences SBF007\100054Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/12165-8Royal Society IEC\NSFC\201116Wellcome Trust
6 · The paper itself

Abstract

To evaluate the safety and the potential antiviral treatment of inhaled enriched heparin in patients with COVID-19. The specific objectives were to investigate the anticoagulation profile, antiviral and anti-inflammatory effects, and respiratory evolution of inhaled enriched heparin. We conducted a randomized, triple-blind, placebo-controlled Phase I/II clinical trial in hospitalized adults with COVID-19 receiving inhalation of enriched heparin or saline (placebo) every 4 h for 7 days. Among the 27 patients who completed the study, no changes in blood coagulation parameters were observed, indicating the safety of inhaled enriched heparin. The group receiving enriched heparin showed a significant reduction in the need for supplemental oxygen and improvement in respiratory parameters, such as the PaO

Indexed as

AnticoagulantsCOVID-19COVID-19 Drug TreatmentHeparinAdministration, InhalationAdultAgedAntiviral AgentsFemaleHumansMaleMiddle AgedNebulizers and VaporizersSARS-CoV-2Treatment OutcomeAnticoagulantsAntiviral AgentsHeparinCOVID-19Enriched heparinSafetySARS-CoV-2Treatment

Identifiers

PMID39191809
PMCPMC11350104

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.