Evidence map›Paper›PMID 39192919›Full record

ArticleCureus2024

Cytoprotective Effect of Growth Factors Derived From Platelets on Corticosteroid-Treated Primary Anterior Cruciate Ligament-Derived Stromal Cells and Chondrocytes.

Vijay Sharma, Ulka Sakhalkar, Pratiksha Nadkarni, Rashmi Mishal, Dinesh Parandhaman, Kirti Vichare, Anjalina Francis, Mudit Khanna, Mohit Kukreja, Anuka Sharma

Abstract read
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. [Application and progress of intelligent responsive hydrogels in articular cartilage injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vijay SharmaDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.
Ulka SakhalkarDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.
Pratiksha NadkarniDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.
Rashmi MishalDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.
Dinesh ParandhamanDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.
Kirti VichareDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.
Anjalina FrancisDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.
Mudit KhannaOrthopaedic Surgery, Wockhardt Hospital, Mumbai, IND.
Mohit KukrejaOrthopaedic Surgery, Wockhardt Hospital, Mumbai, IND.
Anuka SharmaDepartment of Regenerative Medicine, Wockhardt Regenerative Pvt. Ltd., Mumbai, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The use of corticosteroids, such as methylprednisolone, for pain management is a common clinical practice. However, it is well known that corticosteroids induce toxicity in anterior cruciate ligament (ACL)-derived stromal cells and chondrocytes. Growth factors from platelets have anti-inflammatory effects that can potentially limit the cytotoxic effects of corticosteroids. In this study, we explored the role of growth factors obtained from the Ossinext

Indexed as

acl-derived stromal cellschondrocytesglucocorticoidsimmunocytochemistrymusculoskeletal diseaseplatelet growth factors

Identifiers

PMID39192919
PMCPMC11348450

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.