Evidence map›Paper›PMID 39193869›Full record

ArticleArtificial organs2025

Impact of device variability and protocol differences on kidney function during normothermic machine perfusion: A comparative study using porcine and human kidneys.

Veerle A Lantinga, Asel S Arykbaeva, Nora A Spraakman, Elwin W P Blom, Tobias M Huijink, Dorottya K de Vries, Rutger J Ploeg, Ian P J Alwayn, Henri G D Leuvenink, Cyril Moers and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Veerle A LantingaDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-6931-2825
Asel S ArykbaevaDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0002-2918-171X
Nora A SpraakmanDepartment of Anaesthesiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0001-8614-589X
Elwin W P BlomDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Tobias M HuijinkDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-5450-1009
Dorottya K de VriesDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-2206-3929
Rutger J PloegDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0001-7801-665X
Ian P J AlwaynDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0003-0603-9849
Henri G D LeuveninkDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0001-5036-2999
Cyril MoersDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0001-8014-8387
L Leonie van LeeuwenDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-4666-2993

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA growing interest in renal normothermic machine perfusion (NMP) has resulted in more clinically available perfusion devices. While all perfusion systems have the same aim, there are significant differences in their circuits, pumps, sensors, and software. Therefore, our objective was to assess the impact of different perfusion protocols and devices on kidney function and perfusion parameters during NMP.

methodsPorcine kidneys were subjected to 30 min of warm ischemia, 24 h of static cold storage, and subsequently perfused for 6 h using (1) the Kidney Assist (KA) machine with a pressure of 75 mm Hg, (2) the KA device incorporating several adjustments and a pressure of 85 mm Hg (modified KA), or (3) the Perlife (PL) perfusion device (n = 4). Consecutively, discarded human kidneys were perfused using the KA or modified KA (n = 3) protocol.

resultsThe PL group quickly reached the device's upper flow limit and consequently received a significantly lower pressure compared to the KA groups. The arterial pO

conclusionsThis study shows that perfusion characteristics and kidney function are significantly influenced by the perfusion protocol and the device and its settings during normothermic machine perfusion and therefore should be interpreted with caution.

Indexed as

KidneyOrgan PreservationPerfusionAnimalsHumansKidney TransplantationOxygen ConsumptionSwineWarm Ischemiakidney transplantationnormothermic machine perfusionperfusion device

Identifiers

PMID39193869
PMCPMC11687212

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.