Evidence map›Paper›PMID 39194671›Full record

ReviewJournal of functional biomaterials2024

Biomaterial Scaffolds for Periodontal Tissue Engineering.

Huanhuan Chen, Guangying Song, Tianmin Xu, Chenda Meng, Yunfan Zhang, Tianyi Xin, Tingting Yu, Yifan Lin, Bing Han

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Embryonic toxicology evaluation of novelJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huanhuan ChenDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.ORCID 0000-0002-4364-627X
Guangying SongDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
Tianmin XuDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
Chenda MengDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
Yunfan ZhangDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
Tianyi XinDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
Tingting YuDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.
Yifan LinDivision of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-2614-9159
Bing HanDepartment of Orthodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China.ORCID 0000-0003-4584-1092

Funding

Beijing Key Program for Research and Application of Clinical Diagnosis and Technology Z211100002921066Health and Medical Research Fund 19201421National clinical key discipline construction project PKUSSNKT-T202102National Key R&D Program of China 2021YFC2400403National Natural Science Foundation of China 51972005, 82071172, 82001082, 82201017Peking University Medicine Fund of Fostering Young Scholars' Scientific and Technological Innovation BMU2022PYB027Project funded by China Postdoctoral Science Foundation 2021M700282, 2022M710257Research Foundation of Peking University School and Hospital of Stomatology PKUSS20210101
6 · The paper itself

Abstract

Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard and soft periodontal tissues. While traditional therapies such as scaling and root planing can effectively halt the disease's progression, they often fail to fully restore the original architecture and function of periodontal tissues due to the limited capacity for spontaneous regeneration. To address this challenge, periodontal tissue engineering has emerged as a promising approach. This technology centers on the utilization of biomaterial scaffolds, which function as three-dimensional (3D) templates or frameworks, supporting and guiding the regeneration of periodontal tissues, including the periodontal ligament, cementum, alveolar bone, and gingival tissue. These scaffolds mimic the extracellular matrix (ECM) of native periodontal tissues, aiming to foster cell attachment, proliferation, differentiation, and, ultimately, the formation of new, functional periodontal structures. Despite the inherent challenges associated with preclinical testing, the intensification of research on biomaterial scaffolds, coupled with the continuous advancement of fabrication technology, leads us to anticipate a significant expansion in their application for periodontal tissue regeneration. This review comprehensively covers the recent advancements in biomaterial scaffolds engineered specifically for periodontal tissue regeneration, aiming to provide insights into the current state of the field and potential directions for future research.

Indexed as

biomaterialsperiodontal tissue regenerationperiodontitisscaffoldstissue engineering

Identifiers

PMID39194671
PMCPMC11355167

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.