Evidence map›Paper›PMID 39195235›Full record

ArticleCells2024

Mutation in the Kinase Domain Alters the VEGFR2 Membrane Dynamics.

Michela Corsini, Cosetta Ravelli, Elisabetta Grillo, Mattia Domenichini, Stefania Mitola

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michela CorsiniDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-8673-4376
Cosetta RavelliDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-3554-6711
Elisabetta GrilloDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-8403-0607
Mattia DomenichiniDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Stefania MitolaDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-5557-738X

Funding

AIRC IG17276Cariplo Foundation #2022-0316PNRR M4C2-Investimento 1.4-CN00000041 finanziato dall'Unione Europea-NextGenerationEU CN3
6 · The paper itself

Abstract

backgroundRecently, the substitution R1051Q in VEGFR2 has been described as a cancer-associated "gain of function" mutation. VEGFR2

methodsWe employed quantitative FLIM/FRET and FRAP imaging techniques using CHO cells co-transfected with the two forms of VEGFR2 to mimic heterozygosity.

resultsMembrane protein biotinylation reveals that VEGFR2

conclusionsThis study demonstrates that active VEGFR2

Indexed as

Cell MembraneMutationVascular Endothelial Growth Factor Receptor-2AnimalsCHO CellsCricetulusHumansPhosphorylationProtein DomainsProtein MultimerizationSignal TransductionKDR protein, humanVascular Endothelial Growth Factor Receptor-2FLIM/FRETFRAPmolecular interactionTK receptorsVEGFR2

Identifiers

PMID39195235
PMCPMC11352761

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.