Evidence map›Paper›PMID 39195246›Full record

ArticleCells2024

The Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association with Tumor Stromal Inflammation.

Raymond L Konger, Xiaoling Xuei, Ethel Derr-Yellin, Fang Fang, Hongyu Gao, Yunlong Liu

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raymond L KongerDepartment of Pathology & Laboratory Medicine, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.ORCID 0000-0002-4923-2406
Xiaoling XueiDepartment of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Ethel Derr-YellinDepartment of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Fang FangDepartment of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Hongyu GaoDepartment of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Yunlong LiuDepartment of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2699-626X

Funding

Regulation of cutaneous immune function and anti-tumor immune responses by PPARgamma-mediated transrepressive signalingI01BX003762 · VA · RLR VA MEDICAL CENTER · PI KONGER, RAYMOND L · 2017 to 2021
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Promotion of photocarcinogenesis by the senescent field and mechanisms for field persistenceI01BX005816 · VA · RLR VA MEDICAL CENTER · PI KONGER, RAYMOND L · 2022 to 2025
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BLRD VA I01 BX003762BLRD VA I01 BX005816
6 · The paper itself

Abstract

Given the importance of peroxisome proliferator-activated receptor (PPAR)-gamma in epidermal inflammation and carcinogenesis, we analyzed the transcriptomic changes observed in epidermal PPARγ-deficient mice (

Indexed as

Carcinoma, Squamous CellInflammationKeratosis, ActinicPPAR gammaSignal TransductionSkin NeoplasmsAnimalsGene Expression Regulation, NeoplasticHumansMiceStromal CellsPPAR gammaactinic keratosescutaneous squamous cell carcinomagene set enrichment analysisinflammationnon-melanoma skin cancerperoxisome proliferator-activated receptortranscriptomicstumor suppression

Identifiers

PMID39195246
PMCPMC11352891

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.