Evidence map›Paper›PMID 39195919›Full record

ArticleNature cardiovascular research2023

Functional analysis of a common BAG3 allele associated with protection from heart failure.

Juan A Perez-Bermejo, Luke M Judge, Christina L Jensen, Kenneth Wu, Hannah L Watry, Annie Truong, Jaclyn J Ho, Matthew Carter, Wendy V Runyon, Robyn M Kaake and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juan A Perez-BermejoGladstone Institutes, San Francisco, CA, USA.
Luke M JudgeGladstone Institutes, San Francisco, CA, USA.
Christina L JensenGladstone Institutes, San Francisco, CA, USA.
Kenneth WuGladstone Institutes, San Francisco, CA, USA.
Hannah L WatryGladstone Institutes, San Francisco, CA, USA.
Annie TruongGladstone Institutes, San Francisco, CA, USA.
Jaclyn J HoTenaya Therapeutics, South San Francisco, CA, USA.ORCID 0000-0001-9166-5953
Matthew CarterGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0003-1705-0090
Wendy V RunyonGladstone Institutes, San Francisco, CA, USA.
Robyn M KaakeGladstone Institutes, San Francisco, CA, USA.
Ernst H PulidoGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-3616-9743
Mohammad A MandegarTenaya Therapeutics, South San Francisco, CA, USA.
Danielle L SwaneyGladstone Institutes, San Francisco, CA, USA.
Po-Lin SoGladstone Institutes, San Francisco, CA, USA.
Nevan J KroganGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0003-4902-337X
Bruce R ConklinGladstone Institutes, San Francisco, CA, USA. bconklin@gladstone.ucsf.edu.ORCID 0000-0003-1463-6061

Funding

Project 3: Control of cardiac transcription by MEF2 and myocardinP01HL146366 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BLACK, BRIAN L · 2019 to 2023
$13.7M
Protein quality control, cardiomyopathy, cardiotoxicity and human isogenic iPSCsR01HL135358 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI CONKLIN, BRUCE R · 2017 to 2020
$2.0M
Child Health Career Development Program at UCSFK12HD072222 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 2013 to 2017
$2.0M
Identifying Therapeutic Targets for RNA Splicing-Related CardiomyopathyR01HL130533 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI CONKLIN, BRUCE R · 2016 to 2019
$1.8M
Reactivation of Innate Immune Response Pathways as Treatment for HIV InfectionF32AI127291 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI KAAKE, ROBYN MIDORI · 2016 to 2018
$178k
Bristol-Myers Squibb Foundation (BMSF) 63376California Institute for Regenerative Medicine (CIRM) TG2-01160Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) F32AI127291Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01-HL130533Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01-HL13535801NHLBI NIH HHS P01 HL146366NHLBI NIH HHS R01 HL130533NHLBI NIH HHS R01 HL135358NIAID NIH HHS F32 AI127291NICHD NIH HHS K12 HD072222U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1K12HD072222
6 · The paper itself

Abstract

Multiple genetic association studies have correlated a common allelic block linked to the BAG3 gene with a decreased incidence of heart failure, but the molecular mechanism remains elusive. In this study, we used induced pluripotent stem cells to test if the only coding variant in this allele block, BAG3

Indexed as

Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsHeart FailureInduced Pluripotent Stem CellsMyocytes, CardiacAllelesGenetic Predisposition to DiseaseHaplotypesHumansPhenotypeAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBAG3 protein, human

Identifiers

PMID39195919
PMCPMC12360617

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.