Evidence map›Paper›PMID 39195936›Full record

ArticleNature cardiovascular research2024

Development and multinational validation of an algorithmic strategy for high Lp(a) screening.

Arya Aminorroaya, Lovedeep S Dhingra, Evangelos K Oikonomou, Seyedmohammad Saadatagah, Phyllis Thangaraj, Sumukh Vasisht Shankar, Erica S Spatz, Rohan Khera

Abstract readValidation StudyMulticenter Study
In one paragraph

Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Lipoprotein (a) in primary cardiovascular disease prevention is actionable today.American heart journal plus : cardiology research and practice · 2025
    Review
  4. Article
  5. Article
  6. Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arya AminorroayaSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3197-2657
Lovedeep S DhingraSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5664-4126
Evangelos K OikonomouSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4362-0720
Seyedmohammad SaadatagahDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Phyllis ThangarajSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Sumukh Vasisht ShankarSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0005-3034-0641
Erica S SpatzSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Rohan KheraSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. rohan.khera@yale.edu.ORCID 0000-0001-9467-6199

Funding

Translating Personalized Inference from Randomized Clinical Trials to Real-World Cardiovascular CareR01HL167858 · NHLBI · YALE UNIVERSITY · PI Rohan Khera · 2024 to 2026
$2.3M
Evaluating and Improving Utilization of Evidence-Based Medical Therapy in Patients with Heart Failure using Automated Tools in the Electronic Health RecordK23HL153775 · NHLBI · YALE UNIVERSITY · PI KHERA, ROHAN · 2021 to 2025
$918k
A multi-modal approach for efficient, point-of-care screening of hypertrophic cardiomyopathyF32HL170592 · NHLBI · YALE UNIVERSITY · PI OIKONOMOU, EVANGELOS · 2023 to 2024
$166k
Doris Duke Charitable Foundation (DDCF) 2022060NHLBI NIH HHS F32 HL170592NHLBI NIH HHS K23 HL153775NHLBI NIH HHS R01 HL167858U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K23HL153775
6 · The paper itself

Abstract

Elevated lipoprotein (a) (Lp(a)) is associated with premature atherosclerotic cardiovascular disease. However, fewer than 0.5% of individuals undergo Lp(a) testing, limiting the evaluation and use of novel targeted therapeutics currently under development. Here we describe the development of a machine learning model for targeted screening for elevated Lp(a) (≥150 nmol l

Indexed as

AlgorithmsBiomarkersLipoprotein(a)Machine LearningAdultAgedCardiovascular DiseasesDecision Support TechniquesFemaleHumansMaleMass ScreeningMiddle AgedPredictive Value of TestsReproducibility of ResultsRisk AssessmentBiomarkersLipoprotein(a)LPA protein, human

Identifiers

PMID39195936
PMCPMC12190734

What Socratic holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.