Evidence mapPaperPMID 39196801Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2024

Enhanced ECCD36 signaling promotes skeletal muscle insulin resistance in female mice.

Austin Dada, Javad Habibi, Huma Naz, Dongqing Chen, Guido Lastra, Brian P Bostick, Adam Whaley-Connell, Michael A Hill, James R Sowers, Guanghong Jia

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Austin DadaDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.
Javad HabibiDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.
Huma NazDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.ORCID 0000-0002-1989-7466
Dongqing ChenDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.
Guido LastraDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.ORCID 0000-0001-9205-1021
Brian P BostickDepartment of Medicine-Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, Missouri, United States.ORCID 0000-0001-5628-0249
Adam Whaley-ConnellDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.
Michael A HillDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, United States.
James R SowersDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.
Guanghong JiaDepartment of Medicine-Endocrinology and Metabolism, University of Missouri School of Medicine, Columbia, Missouri, United States.ORCID 0000-0003-0018-5925

Funding

Endothelial mineralocorticoid receptors in diet-induced skeletal muscle insulin resistanceR01DK124329 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · 2022 to 2025
$1.5M
Epithelial sodium channels in endothelial cells and arterial stiffeningR01HL172875 · UNIVERSITY OF MISSOURI-COLUMBIA · 2025 to 2025
$503k
Cell Specific Mineralocorticoid Signaling, Insulin Resistance and Cardiovascular StiffnessI01BX001981 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI Guido Lastra · 2021 to 2022
BLRD VA I01 BX001981BLRD VA I01 BX003391HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL172875HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK124329NHLBI NIH HHS R01 HL172875NIDDK NIH HHS R01 DK124329U.S. Department of Veterans Affairs (VA) 5101BX001981U.S. Department of Veterans Affairs (VA) BX003391
6 · The paper itself

Abstract

Consumption of a Western diet (WD) increases CD36 expression in vascular, hepatic, and skeletal muscle tissues promoting lipid metabolic disorders and insulin resistance. We further examined the role of endothelial cell-specific CD36 (ECCD36) signaling in contributing to skeletal muscle lipid metabolic disorders, insulin resistance, and their underlying molecular mechanisms. Female ECCD36 wild-type (ECCD36

Indexed as

CD36 AntigensDiet, WesternInsulin ResistanceMuscle, SkeletalSignal TransductionAnimalsEndothelial CellsFemaleInsulinLipid MetabolismMiceMice, Inbred C57BLMice, KnockoutCD36 AntigensCd36 protein, mouseInsulinCD36endothelial cellsinsulin resistanceobesityskeletal muscle

Identifiers

PMID39196801
PMCPMC11482271

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.