Evidence map›Paper›PMID 39197730›Full record

ArticleGenomics2024

Brain lncRNA-mRNA co-expression regulatory networks and alcohol use disorder.

Ojong Tabi Ojong Besong, Ji Sun Koo, Huiping Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ojong Tabi Ojong BesongDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Section of Biomedical Genetics, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Ji Sun KooDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Section of Biomedical Genetics, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Huiping ZhangDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Section of Biomedical Genetics, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: huipingz@bu.edu.

Funding

Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use DisorderR01AA029758 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Huiping Zhang · 2022 to 2026
$2.8M
Brain microRNA-mRNA regulatory networks and alcohol use disordersR01AA025080 · NIAAA · YALE UNIVERSITY · PI ZHANG, HUIPING · 2016 to 2020
$1.7M
NIAAA NIH HHS R01 AA025080NIAAA NIH HHS R01 AA029758NIAAA NIH HHS R28 AA012725
6 · The paper itself

Abstract

Prolonged alcohol consumption can disturb the expression of both coding and noncoding genes in the brain. These dysregulated genes may co-express in modules and interact within networks, consequently influencing the susceptibility to developing alcohol use disorder (AUD). In the present study, we performed an RNA-seq analysis of the expression of both long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) in 192 postmortem tissue samples collected from eight brain regions (amygdala, caudate nucleus, cerebellum, hippocampus, nucleus accumbens, prefrontal cortex, putamen, and ventral tegmental area) of 12 AUD and 12 control subjects of European ancestry. Applying the limma-voom method, we detected a total of 57 lncRNAs and 51 mRNAs exhibiting significant differential expression (P

Indexed as

AlcoholismBrainGene Regulatory NetworksRNA, Long NoncodingRNA, MessengerFemaleHumansMachine LearningMaleRNA, Long NoncodingRNA, MessengerAlcohol use disorderBrain reward circuitryGene co-expressionHuman postmortem brain tissuesLncRNA-mRNA networksMachine learningrRNA depletion RNA-seq

Identifiers

PMID39197730
PMCPMC11531342

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.