Evidence map›Paper›PMID 39197865›Full record

Trial reportPediatric obesity2025

Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children.

Dabin Yeum, Timothy J Renier, Travis D Masterson, Delaina D Carlson, Grace A Ballarino, Reina K Lansigan, Ruth J F Loos, Jennifer A Emond, Diane Gilbert-Diamond

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dabin YeumDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0001-9575-4849
Timothy J RenierDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0001-8949-0090
Travis D MastersonDepartment of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania, USA.
Delaina D CarlsonDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.
Grace A BallarinoDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.
Reina K LansiganDepartment of Pediatrics, Geisel School of Medicine at Dartmouth College, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Ruth J F LoosNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty for Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jennifer A EmondDepartment of Pediatrics, Geisel School of Medicine at Dartmouth College, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.ORCID https://orcid.org/0000-0001-8684-7330
Diane Gilbert-DiamondDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · 1985 to 2025
$35.3M
Song - Proj 3P20GM130454 · DARTMOUTH COLLEGE · 2025 to 2025
$2.4M
Dartmouth Training Program in Quantitative Cancer ResearchT32CA260262 · NCI · DARTMOUTH COLLEGE · 2023 to 2025
$401k
Dartmouth Cancer Center 5P30CA023108Dartmouth Cancer Center P20GM130454NCI NIH HHS P30 CA023108NCI NIH HHS T32 CA260262NCI NIH HHS T32CA260262NICHD NIH HHS R01 HD092604NIGMS NIH HHS P20 GM130454NIH HHS 5R01HD092604
6 · The paper itself

Abstract

objectiveThe objective of this study is to evaluate obesity-related genetic factors in relation to excess consumption and assess if food cues modify associations.

methodsChildren (9-12 years) completed a randomized crossover experiment. During two visits, children ate a preload and then snacks ad libitum while watching television, embedded with food or non-food advertisements to assess eating in the absence of hunger (EAH). Primary exposures were obesity-associated genotypes, FTO rs9939609 and MC4R rs571312, and a paediatric-specific polygenic risk score (PRS). Outcomes included consumption of all snacks (total EAH) and gummy candy only (gummy candy EAH). Linear mixed-effects models tested whether genetic exposures related to EAH outcomes. We tested for effect modification by food cues using multiplicative interaction terms.

resultsAmong 177 children, each FTO risk allele was associated with a 30% increase in gummy candy EAH (p = 0.025) in adjusted models. Food cue exposure exacerbated associations between the FTO variant with gummy candy EAH (p = 0.046). No statistically significant associations were found between MC4R and EAH.

conclusionThe results suggest children with the FTO rs9939609 risk allele may be predisposed to excess consumption of candy and that this association may be exacerbated by food cues.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOCuesFeeding BehaviorPediatric ObesityReceptor, Melanocortin, Type 4ChildCross-Over StudiesFemaleGenotypeHumansHungerMalePolymorphism, Single NucleotideSnacksAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanMC4R protein, humanReceptor, Melanocortin, Type 4childreneating in the absence of hungerfood cuesgenotypepolygenic risk score

Identifiers

PMID39197865
PMCPMC11868456

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.