Evidence map›Paper›PMID 39198755›Full record

ArticleBMC gastroenterology2024

Genetic associations of birthweight, childhood, and adult BMI with metabolic dysfunction-associated steatotic liver disease: a Mendelian randomization.

Xiaohui Ma, Lina Chang, Shuo Li, Yian Gu, Jieying Wan, Hequn Sang, Li Ding, Ming Liu, Qing He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaohui Ma *Department of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China.
Lina Chang *Department of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China.
Shuo Li *Department of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China.
Yian GuDepartment of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China.
Jieying WanDepartment of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China.
Hequn SangDepartment of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China.
Li DingDepartment of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China. dinglitml@tmu.edu.cn.
Ming LiuDepartment of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China. mingliu@tmu.edu.cn.
Qing HeDepartment of Endocrinology and Metabolism, Tianjin Medical University Genaral Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, Tianjin, China. heqing202108@163.com.

Funding

Major Project of Tianjin Municipal Science and Technology Bureau 21ZXJBSY00060the National Natural Science Foundation of China 82200882Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-030A
6 · The paper itself

Abstract

purposeThe causal relationship between life course adiposity with metabolic dysfunction-associated steatotic liver disease (MASLD) is ambiguous. We aimed to investigate whether there is an independent genetic causal relationship between body size at various life course and MASLD.

methodsWe performed univariable and multivariable Mendelian randomization (MR) to estimate the causal effect of body size at different life stages on MASLD (i.e., defined by the clinical comprehensive diagnosis from the electronic health record [HER] codes [ICD9/ICD10] or diagnostic phrases), including birthweight, childhood body mass index (BMI), adult BMI, waist circumference (WC), waist-to-hip ratio (WHR), body fat percentage (BFP).

resultsIn univariate analyses, higher genetically predicted lower birthweight (OR

conclusionFor the first time, this MR elucidated new evidence for the effect of life course adiposity on MASLD risk, providing lower birthweight and duration of obesity are independent risk factors for MASLD. Our findings indicated that weight management during distinct time periods plays a significant role in the prevention and treatment of MASLD.

Indexed as

AdiposityBirth WeightBody Mass IndexMendelian Randomization AnalysisAdultChildFatty LiverFemaleHumansMaleRisk FactorsWaist CircumferenceAdult body mass indexBirthweightChildhood body mass indexMendelian randomizationMetabolic dysfunction-associated steatotic liver disease

Identifiers

PMID39198755
PMCPMC11351507

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.