Evidence map›Paper›PMID 39199236›Full record

ArticleAntioxidants (Basel, Switzerland)2024

The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase.

Kenneth R Olson, Tsuyoshi Takata, Kasey J Clear, Yan Gao, Zhilin Ma, Ella Pfaff, Karthik Mouli, Thomas A Kent, Prentiss Jones, Jon Fukuto and 2 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Antioxidants (Basel, Switzerland) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kenneth R OlsonDepartment of Physiology, Indiana University School of Medicine South Bend, South Bend, IN 46617, USA.ORCID 0000-0003-0178-2203
Tsuyoshi TakataDepartment of Physiology, Indiana University School of Medicine South Bend, South Bend, IN 46617, USA.ORCID 0000-0002-6691-2569
Kasey J ClearDepartment of Chemistry and Biochemistry, Indiana University South Bend, South Bend, IN 46615, USA.ORCID 0000-0001-8628-681X
Yan GaoDepartment of Physiology, Indiana University School of Medicine South Bend, South Bend, IN 46617, USA.
Zhilin MaDepartment of Physiology, Indiana University School of Medicine South Bend, South Bend, IN 46617, USA.ORCID 0000-0003-2493-0889
Ella PfaffDepartment of Physiology, Indiana University School of Medicine South Bend, South Bend, IN 46617, USA.
Karthik MouliInstitute of Biosciences and Technology, Texas A&M Health Sciences Center-Houston Campus, Houston, TX 77030, USA.
Thomas A KentInstitute of Biosciences and Technology, Texas A&M Health Sciences Center-Houston Campus, Houston, TX 77030, USA.ORCID 0000-0002-9877-7584
Prentiss JonesToxicology Department, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI 49007, USA.ORCID 0009-0000-5842-3944
Jon FukutoDepartment of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA.
Gang WuDepartment of Internal Medicine, McGovern Medical School, University of Texas, Houston, TX 77030, USA.ORCID 0000-0001-6803-0853
Karl D StraubCentral Arkansas Veteran's Healthcare System, Little Rock, AR 72205, USA.

Funding

Novel Carbon Nanozyme Mechanisms for Traumatic Brain InjuryR01NS094535 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HEGDE, MURALIDHAR L, KENT, THOMAS · 2015 to 2024
$4.1M
CSRD VA 1National Science Foundation IOS2012106NINDS NIH HHS R01 NS094535
6 · The paper itself

Abstract

LCS-1, a putative selective inhibitor of SOD1, is a substituted pyridazinone with rudimentary similarity to quinones and naphthoquinones. As quinones catalytically oxidize H

Indexed as

antioxidantsreactive oxygen speciesreactive sulfur speciesSOD1SOD2

Identifiers

PMID39199236
PMCPMC11351665

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.