Evidence mapPaperPMID 39199405Full record

ArticleBiomolecules2024

Novel Insights into the Antimicrobial and Antibiofilm Activity of Pyrroloquinoline Quinone (PQQ);

Mai M Labib, Alaa M Alqahtani, Hebatallah H Abo Nahas, Rana M Aldossari, Bandar Fahad Almiman, Sarah Ayman Alnumaani, Mohammad El-Nablaway, Ebtesam Al-Olayan, Maha Alsunbul, Essa M Saied

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mai M LabibDepartment of Bioinformatics, Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Centre (ARC), Cairo 12619, Egypt.ORCID 0000-0002-0506-4172
Alaa M AlqahtaniDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-8845-2786
Hebatallah H Abo NahasZoology Department, Faculty of Science, Port Said University, Port Said 42526, Egypt.
Rana M AldossariDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Bandar Fahad AlmimanBiology Department, College of Science, Al-Baha University, Al Bahah 65779, Saudi Arabia.
Sarah Ayman AlnumaaniDepartment of Medical Microbiology, Faculty of Medicine, University of Jeddah, Jeddah 23218, Saudi Arabia.
Mohammad El-NablawayDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.ORCID 0000-0003-2494-6004
Ebtesam Al-OlayanDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-4041-9848
Maha AlsunbulDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Essa M SaiedChemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0002-7342-6200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial infections pose a significant global health threat, affecting millions of individuals and leading to substantial mortality rates. The increasing resistance of microorganisms to conventional treatments requires the development of novel antimicrobial agents. Pyrroloquinoline quinone (PQQ), a natural medicinal drug involved in various cellular processes, holds promise as a potential antimicrobial agent. In the present study, our aim was, for the first time, to explore the antimicrobial activity of PQQ against 29 pathogenic microbes, including 13 fungal strains, 8 Gram-positive bacteria, and 8 Gram-negative bacteria. Our findings revealed potent antifungal properties of PQQ, particularly against

Indexed as

BiofilmsMicrobial Sensitivity TestsPQQ CofactorProteomicsAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsComputer SimulationFungiGram-Negative BacteriaGram-Positive BacteriaMolecular Docking SimulationAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsPQQ Cofactorantibacterial activityantibiofilm activityantifungal activityantimicrobial agentsmolecular modelingMRSApyrroloquinoline quinoneshotgun proteomic analysisTEM analysis

Identifiers

PMID39199405
PMCPMC11352295

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.