Evidence map›Paper›PMID 39199639›Full record

ArticleCancers2024

Molecular Analysis of Salivary and Lacrimal Adenoid Cystic Carcinoma.

Sarah Powell, Karina Kulakova, Katie Hanratty, Rizwana Khan, Paula Casserly, John Crown, Naomi Walsh, Susan Kennedy

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah PowellResearch Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, D02 XK51 Dublin, Ireland.
Karina KulakovaNational Ophthalmic Pathology Laboratory, D04 T6F6 Dublin, Ireland.ORCID 0009-0006-1289-084X
Katie HanrattyResearch Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, D02 XK51 Dublin, Ireland.
Rizwana KhanResearch Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, D02 XK51 Dublin, Ireland.
Paula CasserlyResearch Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, D02 XK51 Dublin, Ireland.
John CrownSt. Vincent's University Hospital, D04 T6F4 Dublin, Ireland.
Naomi WalshSchool of Biotechnology, Dublin City University, D09 V209 Dublin, Ireland.ORCID 0000-0002-2178-3564
Susan KennedyNational Ophthalmic Pathology Laboratory, D04 T6F6 Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenoid cystic carcinoma (ACC) of head and neck origin is associated with slow but relentless progression and systemic metastasis, resulting in poor long-term survival rates. ACC does not respond to conventional chemotherapy. Determination of molecular drivers may provide a rational basis for personalized therapy. Herein, we investigate the clinical and detailed molecular genomic features of a cohort of patients treated in Ireland and correlate the site of origin, molecular features, and outcomes. Clinical and genomic landscapes of all patients diagnosed with ACC over a twenty-year period (2002-2022) in a single unit in Ireland were examined and analyzed using fluorescence in situ hybridization, DNA sequencing, and bioinformatic analysis. Fourteen patients were included for analysis. Eleven patients had primary salivary gland ACC and three primary lacrimal gland ACC; 76.9% of the analyzed tumors displayed evidence of

Indexed as

adenoid cystic carcinomaDNA damage repairepigenetic modificationsNFIB-MYBNOTCH

Identifiers

PMID39199639
PMCPMC11353050

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.